ArticleClinical and experimental immunology1985
Simultaneous induction of rheumatoid factor- and antigen-specific antibody-secreting cells during the secondary immune response in man.
Article in Clinical and experimental immunology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 84 citations in OpenAlex.
- Sulphasalazine inhibits human antigen-specific immune responses in vivo.Annals of the rheumatic diseases · 2007Trial
- Review
- Longitudinal rheumatoid factor autoantibody responses after SARS-CoV-2 vaccination or infection.Frontiers in immunology · 2024Review
- New Relationships for Old Autoantibodies in Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Complex Relationships of Smoking, HLA-DRB1 Genes, and Serologic Profiles in Patients With Early Rheumatoid Arthritis: Update From a Swedish Population-Based Case-Control Study.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis.Nature reviews. Rheumatology · 2014Review
- Cryptic B cell response to renal transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Article
- Enzyme-linked immunospot assays for direct ex vivo measurement of vaccine-induced human humoral immune responses in blood.Nature protocols · 2013Article
- Crystal structure of a human autoimmune complex between IgM rheumatoid factor RF61 and IgG1 Fc reveals a novel epitope and evidence for affinity maturation.Journal of molecular biology · 2007Article
- Rheumatoid factor and antibodies to cyclic citrullinated peptides are associated with severe extra-articular manifestations in rheumatoid arthritis.Annals of the rheumatic diseases · 2007Article
- Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cells.Arthritis research & therapy · 2006Article
- Detection and characterization of plasma cells in peripheral blood: correlation of IgE+ plasma cell frequency with IgE serum titre.Clinical and experimental immunology · 2002Article
- Differential requirements for induction of total immunoglobulin and physiological rheumatoid factor production by human peripheral blood B cells.Clinical and experimental immunology · 2001Article
- Intestinal immune responses to an inactivated oral enterotoxigenic Escherichia coli vaccine and associated immunoglobulin A responses in blood.Infection and immunity · 1998Article
- ELISPOT assay for Chlamydia-specific, antibody-producing cells correlated with conventional complement fixation and microimmunofluorescence.Journal of clinical laboratory analysis · 1997Article
- The gut as an inductive site for synovial and extra-articular immune responses in rheumatoid arthritis.Annals of the rheumatic diseases · 1994Article
- Monospecific but not polyreactive human hybridoma rheumatoid factors exhibit preferential binding specificities for IgG3 and IgG4.Rheumatology international · 1994Article
- Rheumatoid factor production by mononuclear cells derived from different sites of patients with rheumatoid arthritis.Clinical and experimental immunology · 1993Article
- Enumeration of human peripheral blood lymphocytes secreting immunoglobulins of major classes and subclasses in healthy children and adults.Journal of clinical immunology · 1991Article
- Intra-articular immunization induces strong systemic immune response in humans.Clinical and experimental immunology · 1990Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The production of anti-tetanus toxoid antibody and rheumatoid factor (RF) by individual peripheral blood mononuclear cells (PBMC) was studied at various times after booster immunization of healthy volunteers with tetanus toxoid (TT). TT-specific antibody-secreting cells and RF-secreting cells were assayed by the enzyme-linked immunospot (ELISPOT) assay. Cells obtained 5-9 days after immunization were found to spontaneously secrete TT-specific antibodies. This response was specific for the immunogen, was abrogated by cycloheximide and accounted for most of the immunoglobulins produced. TT-specific antibody-secreting cells were found concomitantly with cells secreting RF, mainly of the IgM isotype. Elevated levels of circulating immune complexes (CIC) containing IgG and C3 were observed shortly before the appearance of both TT-specific antibody-secreting cells and IgM RF-secreting cells. Thus, after booster immunization with TT, two major subpopulations of immunoglobulin-secreting cells appear concomitantly in the peripheral circulation: a population of cells secreting TT-specific antibody and a population of cells secreting IgM RF. It is suggested that RF production in man represents a physiological event which might be triggered by IgG-containing immune complexes formed during a secondary immune response.
Indexed as
Identifiers
2412746PMC1577317W313848116What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.