ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Age, comorbidities, and AIDS predict a frailty phenotype in men who have sex with men.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
124 citing papers in PubMed, 1 synthesis or guideline pooled it, 204 citations in OpenAlex.
- Physical function, grip strength and frailty in people living with HIV in sub-Saharan Africa: systematic review.Tropical medicine & international health : TM & IH · 2017Pooled it
- Establishing the feasibility, acceptability and preliminary efficacy of a multi-component behavioral intervention to reduce pain and substance use and improve physical performance in older persons living with HIV.Journal of substance abuse treatment · 2019Trial
- Frailty and Clinical Outcomes in Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2019Trial
- The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV.The Journal of frailty & aging · 2019Trial
- Gender differences for frailty in HIV-infected patients on stable antiretroviral therapy and with an undetectable viral load.PloS one · 2019Trial
- Antiretroviral initiation is associated with increased skeletal muscle area and fat content.AIDS (London, England) · 2017Trial
- Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects.BMC immunology · 2015Trial
- Five-year disability trajectories and associated factors among adults aging with HIV in the Ontario HIV Treatment Network Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH): a clinical trial protocol.BMJ open · 2026Article
- SIV infection induces aging-like alterations in cardiac cellularity and macrophage populations of rhesus macaques.Journal of leukocyte biology · 2026Article
- Modeled Health and Economic Burden of Frailty and Falls Among Adults With HIV.JAMA network open · 2026Article
- High Enrollment and Representativeness of MACS and WIHS Study Participants in the newly merged MACS/WIHS Combined Cohort Study (MWCCS).AJE advances : research in epidemiology · 2026Article
- Prevalence and factors associated with frailty among older adults with and without HIV in Kampala, Uganda.AIDS research and therapy · 2025Article
- Predictors of frailty trajectories among people with HIV.AIDS (London, England) · 2025Observational
- Alcohol Use and Its Associations With Frailty, Fractures, and Falls Among Older Adults With HIV.Alcohol research : current reviews · 2025Review
- Article
- Current Challenges, Solutions, and Novel Directions in Research and Clinical Care: Proceedings From the 14th Annual International Workshop on HIV and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Muscle Quality and Physical Function in Men With and Without HIV.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Prevalence and Correlates of Frailty Among Older Adults Living With HIV in the CHANGE HIV Cohort.Journal of acquired immune deficiency syndromes (1999) · 2024Article
- Breadth and polyfunctionality of T cell responses to human cytomegalovirus in men who have sex with men: relationship with HIV infection and frailty.Journal of virology · 2024Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAdults aging with HIV infection are at risk for age-related comorbidities and syndromes, such as frailty. The objective of this study was to evaluate the expression and predictors of the frailty phenotype (FP) among HIV-infected (HIV+) and HIV-uninfected (HIV-) men who have sex with men.
methodsA prospective, observational cohort study was nested in the Multicenter AIDS Cohort Study from October 2007-September 2011. FP conversion was defined as the onset of FP over two consecutive study visits. Adjusted odds ratios and 95% confidence intervals ([,]) for FP conversion were estimated using logistic regression models with generalized estimating equations.
resultsOf 10,571 completed study visits from 1,946 men who have sex with men, 12% and 9% were FP+ among HIV+ and HIV- men, respectively (p = .002). The proportion of FP+ visits increased with age regardless of HIV status, but was significantly greater in HIV+ compared to HIV- men aged 50-64 years. Of the 10,276 consecutive visit pairs contributed by participants, 5% (537) were classified as FP conversion, and 45% of the men with FP conversion had only one FP+ study visit. FP conversion was significantly associated with a history of AIDS (adjusted odds ratios = 2.26 [1.50, 3.39], but not with HIV+ alone (adjusted odds ratios = 1.26 [0.98, 1.64]). Among men who had one or more FP+ visits, 34% of HIV+ and 38% of HIV- men had less than two comorbidities.
conclusionsThese findings suggest that expression of the FP can be measured in men who have sex with men with and without HIV infection and reflects multisystem dysfunction in this population; further investigations are needed to better understand clinical utility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.