ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Sex differences in the limit to deficit accumulation in late middle-aged and older Chinese people: results from the Beijing Longitudinal Study of Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Frailty Change and Major Osteoporotic Fracture in the Elderly: Data from the Global Longitudinal Study of Osteoporosis in Women 3-Year Hamilton Cohort.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Trial
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- The Longitudinal Association between Multiple Frailty Criteria and Depressive Symptomatology Five Years Later in Older Adults: A Decision Tree Modelling Approach.Journal of clinical medicine · 2024Article
- Identification of frailty in primary care: accuracy of electronically derived measures.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
- Development and Validation of 2 Composite Aging Measures Using Routine Clinical Biomarkers in the Chinese Population: Analyses From 2 Prospective Cohort Studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Sex-gender disparities in nonagenarians with acute coronary syndrome.Clinical cardiology · 2021Article
- Frailty Status Among the Elderly of Different Genders and the Death Risk: A Follow-Up Study.Frontiers in medicine · 2021Article
- A self-reported Frailty Index predicts long-term mortality in hospitalized patients with cirrhosis.Annals of translational medicine · 2020Article
- Risk Prediction for Adverse Outcomes for Frail Older Persons with Complex Healthcare and Social Care Needs Admitted to a Community Virtual Ward Model.Clinical interventions in aging · 2020Article
- Sex differences in the relative heterogeneity of frailty in relation to age, frailty, health protection, and five-year mortality.Aging medicine (Milton (N.S.W)) · 2019Article
- Article
- Comparison of Two Models of Frailty for the Prediction of Mortality in Brazilian Community-Dwelling Older Adults: The FIBRA Study.The journal of nutrition, health & aging · 2019Article
- The accumulation of deficits approach to describe frailty.PloS one · 2019Article
- Is frailty a stable predictor of mortality across time? Evidence from the Cognitive Function and Ageing Studies.Age and ageing · 2018Article
- Cognitive Impairment and Risk of All-Cause and Cardiovascular Disease Mortality Over 20-Year Follow-up: Results From the BLSA.Journal of the American Heart Association · 2018Article
- Frailty, the determinants of health and the new evidence base.Aging medicine (Milton (N.S.W)) · 2018Article
- Construct validation of a Frailty Index, an HIV Index and a Protective Index from a clinical HIV database.PloS one · 2018Article
- Development of a Physiological Frailty Index for the World Trade Center General Responder Cohort.Current gerontology and geriatrics research · 2018Article
- Frailty in Relation to the Risk of Alzheimer's Disease, Dementia, and Death in Older Chinese Adults: A Seven-Year Prospective Study.The journal of nutrition, health & aging · 2017Article
- Predictability of frailty index and its components on mortality in older adults in China.BMC geriatrics · 2016Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundOn average, as people age, they accumulate more health deficits and have an increased risk of death. The deficit accumulation-based frailty index (FI) can quantify health and its outcomes in aging. Previous studies have suggested that women show higher FI values than men and that the highest FI score (the "limit to frailty") occurs at a value of FI ~ 0.7. Even so, gender differences in the limit to frailty have not been reported.
methodsData for this analysis were obtained from the Beijing Longitudinal Study of Aging that involved 3,257 community-dwelling Chinese people, aged 55+ years at baseline. The main outcome measure was 5-year mortality. An FI consisting of 35 health-related variables was constructed. The absolute and 99% FI limits were calculated for different age groups and analyzed by sex.
resultsThe mean level of the FI increased with age and was lower in men than in women (F = 67.87, p < .001). The 99% FI limit leveled off slightly earlier with a relatively lower value in men (60 years; 0.44 ± 0.02) compared with that in women (65 years; 0.52 ± 0.04). The highest absolute FI value was 0.61 in men and 0.69 in women. In both groups, people with an FI greater than or equal to the 99% limit showed close to 100% mortality by 5 years.
conclusionCompared with men, women appeared to better tolerate deficits in health, yielding both relatively lower mortality and higher limit values to the FI. Even so, the FI did not exceed 0.7 in any individual.
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