ArticleThe Journal of cell biology2013
DNA methyltransferase-3-dependent nonrandom template segregation in differentiating embryonic stem cells.
Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Non-random Sister Chromatid Segregation Mediated by Ribosomal DNA in Drosophila Male Germline Stem Cells.Advances in experimental medicine and biology · 2026Review
- Cellular and molecular mechanisms of asymmetric stem cell division in tissue homeostasis.Genes to cells : devoted to molecular & cellular mechanisms · 2024Review
- Mitotic drive in asymmetric epigenetic inheritance.Biochemical Society transactions · 2022Article
- Asymmetric Cell Division of Fibroblasts is An Early Deterministic Step to Generate Elite Cells during Cell Reprogramming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Asymmetric inheritance of epigenetic states in asymmetrically dividing stem cells.Current opinion in cell biology · 2020Review
- Haspin-dependent and independent effects of the kinase inhibitor 5-Iodotubercidin on self-renewal and differentiation.Scientific reports · 2020Article
- Asymmetric Histone Inheritance in Asymmetrically Dividing Stem Cells.Trends in genetics : TIG · 2020Review
- Controlled ploidy reduction of pluripotent 4n cells generates 2n cells during mouse embryo development.Science advances · 2019Article
- Emerging mechanisms of asymmetric stem cell division.The Journal of cell biology · 2018Review
- Amar Klar: A giant among scientists (1947-2017).Journal of biosciences · 2017Article
- Split hand/foot malformation genetics supports the chromosome 7 copy segregation mechanism for human limb development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Age-specific functional epigenetic changes in p21 and p16 in injury-activated satellite cells.Stem cells (Dayton, Ohio) · 2015Article
- Linked in: formation and regulation of microtubule attachments during chromosome segregation.Current opinion in cell biology · 2014Review
- Nonrandom template segregation: a way to break the symmetry of stem cells.The Journal of cell biology · 2013Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Asymmetry of cell fate is one fundamental property of stem cells, in which one daughter cell self-renews, whereas the other differentiates. Evidence of nonrandom template segregation (NRTS) of chromosomes during asymmetric cell divisions in phylogenetically divergent organisms, such as plants, fungi, and mammals, has already been shown. However, before this current work, asymmetric inheritance of chromatids has never been demonstrated in differentiating embryonic stem cells (ESCs), and its molecular mechanism has remained unknown. Our results unambiguously demonstrate NRTS in asymmetrically dividing, differentiating human and mouse ESCs. Moreover, we show that NRTS is dependent on DNA methylation and on Dnmt3 (DNA methyltransferase-3), indicating a molecular mechanism that regulates this phenomenon. Furthermore, our data support the hypothesis that retention of chromatids with the "old" template DNA preserves the epigenetic memory of cell fate, whereas localization of "new" DNA strands and de novo DNA methyltransferase to the lineage-destined daughter cell facilitates epigenetic adaptation to a new cell fate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.