Evidence map›Paper›PMID 24127144›Full record

SynthesisJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2013

Serum inflammatory markers in obstructive sleep apnea: a meta-analysis.

Rashid Nadeem, Janos Molnar, Essam M Madbouly, Mahwish Nida, Saurabh Aggarwal, Hassan Sajid, Jawed Naseem, Rohit Loomba

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 270 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
270citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02325687 nacompletednot on this mapstarted 2015, after this paper: background citation

A Pilot Study of Biomarkers in Obstructive Sleep Apnea (OSA): Is There a Correlation Between Cerebrospinal Fluid and Serum Markers of Inflammation in OSA?

TypeinterventionalSponsorHospital for Special Surgery, New YorkRan2015 to 2016Enrolled50ConditionsObstructive Sleep ApneaArmsLumbar Puncture (Standard-of-Care)
NCT03753633 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Efficiency of Speech Therapy in Resistant Hypertensive Patients With Mild Obstructive Sleep Apnea Syndrome

TypeinterventionalSponsorUniversidade Federal do Rio de JaneiroRan2017 to 2019Enrolled50ConditionsSleep Apnea, Obstructive, Hypertension SecondaryArmsSpeech therapy, Control
3 · Its place in the literature

Who cites it

270 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  6. Soluble P-selectin levels in patients with obstructive sleep apnea: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
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210 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rashid NadeemCaptain James A. Lovell Federal Health Care Centre, North Chicago, IL ; Rosalind Franklin University of Medicine and Science/ Chicago Medical School, North Chicago, IL.
Janos Molnar
Essam M Madbouly
Mahwish Nida
Saurabh Aggarwal
Hassan Sajid
Jawed Naseem
Rohit Loomba

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesObstructive sleep apnea (OSA) has been linked to and is associated with increased cardiovascular and cerebrovascular morbidity. Ongoing inflammatory responses play an important role in this association. Multiple small size studies addressing the profile of the inflammatory markers in OSA are available therefore we performed a meta-analysis.

methodsSystematic review of medical literature was conducted using PubMed, Cochrane, and EMBASE databases from 1968 to 2011 by utilizing the key words obstructive sleep apnea, C-Reactive protein, tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 8 (IL-8), intercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM) and Selectins. Inclusion criteria were: full text English articles; studies with adult population; reported values for at least one of the markers of interest; with at least two separate groups (subjects with OSA and control group); OSA was defined as AHI of ≥ 5/h.

resultsFive hundred and twelve studies were reviewed for inclusion with 51 studies pooled for analysis (30 studies for CRP, 19 studies for TNF-α, 8 studies for ICAM, 18 studies for IL-6, six studies for VCAM and 5 studies for Selectins). The levels of inflammatory markers were higher in patients with OSA compared to control group. Standardized pooled Mean differences were calculated to be 1.77 for CRP, 1.03 for TNF-α, 2.16 for IL-6, 4.22 for IL-8, 2.93 for ICAM, 1.45 for Selectins and 2.08 for VCAM.

conclusionsIn this meta-analysis, the levels of systemic inflammatory markers were found to be higher in OSA patients compared to control subjects.

Indexed as

AdultAgedBiomarkersCell Adhesion MoleculesC-Reactive ProteinDisease ProgressionFemaleHumansInflammation MediatorsInterleukin-6Interleukin-8MaleMiddle AgedPolysomnographySelectinsSensitivity and SpecificityBiomarkersCell Adhesion MoleculesC-Reactive ProteinInflammation MediatorsInterleukin-6Interleukin-8SelectinsTumor Necrosis Factor-alphaCRPICAMIL-6IL-8inflammatory markersObstructive sleep apneaSelectinsTNF-αVCAM

Identifiers

PMID24127144
PMCPMC3778171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.