ReviewInflammopharmacology2013
Periprosthetic osteolysis after total hip replacement: molecular pathology and clinical management.
Review in Inflammopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Risk factors for periprosthetic femoral fractures following hip arthroplasty: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Aseptic loosening after total hip arthroplasty and the risk of cardiovascular disease: A nested case-control study.PloS one · 2018Trial
- Oxypaeoniflorin Ameliorates Titanium Particle-Stimulated Osteolysis by Targeting Nrf2 to Reprogram Mitochondrial Homeostasis in Osteoclasts.Journal of cellular and molecular medicine · 2026Article
- Article
- Osteoblasts-derived exosomes as potential novel communicators in particle-induced periprosthetic osteolysis.Materials today. Bio · 2024Article
- Outcome and complication rate of total hip arthroplasty in patients younger than twenty years: which bearing surface should be used?International orthopaedics · 2024Article
- Biomarkers to discriminate between aseptic loosened and stable total hip or knee arthroplasties: a systematic review.EFORT open reviews · 2024Article
- Alumina ceramic-on-ceramic hybrid total hip arthroplasty. A median of 15 years follow-up.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2022Article
- Revealing Inflammatory Indications Induced by Titanium Alloy Wear Debris in Periprosthetic Tissue by Label-Free Correlative High-Resolution Ion, Electron and Optical Microspectroscopy.Materials (Basel, Switzerland) · 2021Article
- Percutaneous cementoplasty of periprosthetic loosening: can interventional radiologists offer an alternative to revision surgery?European radiology · 2021Article
- Mid-term outcomes of the R3™ delta ceramic acetabular system in total hip arthroplasty.Journal of orthopaedic surgery and research · 2021Article
- Cimifugin Suppresses NF-κB Signaling to Prevent Osteoclastogenesis and Periprosthetic Osteolysis.Frontiers in pharmacology · 2021Article
- Reconstruction options and outcomes for acetabular bone loss in revision hip arthroplasty.Orthopedic reviews · 2020Article
- Evidence for Gender-Specific Bone Loss Mechanisms in Periprosthetic Osteolysis.Journal of clinical medicine · 2019Article
- Periprosthetic Osteolysis: Mechanisms, Prevention and Treatment.Journal of clinical medicine · 2019Review
- Metformin protects bone mass in ultra-high-molecular-weight polyethylene particle-induced osteolysis by regulating osteocyte secretion.Journal of bone and mineral metabolism · 2019Article
- NF-κB/let-7f-5p/IL-10 pathway involves in wear particle-induced osteolysis by inducing M1 macrophage polarization.Cell cycle (Georgetown, Tex.) · 2018Article
- Disease-Associated Particulates and Joint Inflammation; Mechanistic Insights and Potential Therapeutic Targets.Frontiers in immunology · 2018Review
- Abrasive Endoprosthetic Wear Particles Inhibit IFN-γ Secretion in Human Monocytes Via Upregulating TNF-α-Induced miR-29b.Inflammation · 2017Article
- Stabilisation of a loosened femoral gamma nail by percutaneous cement injection (cementoplasty): a new technique.Skeletal radiology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periprosthetic osteolysis is a serious complication of total hip replacement (THR) in the medium to long term. Although often asymptomatic, osteolysis can lead to prosthesis loosening and periprosthetic fracture. These complications cause significant morbidity and require complex revision surgery. Here, we review advances in our understanding of the cell and tissue response to particles produced by wear of the articular and non-articular surfaces of prostheses. We discuss the molecular and cellular regulators of osteoclast formation and bone resorptive activity, a better understanding of which may lead to pharmacological treatments for periprosthetic osteolysis. We describe the development of imaging techniques for the detection and measurement of osteolysis around THR prostheses, which enable improved clinical management of patients, provide a means of evaluating outcomes of non-surgical treatments for periprosthetic osteolysis, and assist in pre-operative planning for revision surgery. Finally, there have been advances in the materials used for bearing surfaces to minimise wear, and we review the literature regarding the performance of these new materials to date.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.