ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Polymorphisms in ESR1 and FLJ43663 are associated with breast cancer risk in the Han population.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population.Scientific reports · 2018Trial
- Assessment ofAnnals of medicine · 2024Article
- The association of CASC16 variants with breast Cancer risk in a northwest Chinese female population.Molecular medicine (Cambridge, Mass.) · 2020Article
- Identifying Methylation Pattern and Genes Associated with Breast Cancer Subtypes.International journal of molecular sciences · 2019Article
- The association between interleukin-1 polymorphisms and their protein expression in Chinese Han patients with breast cancer.Molecular genetics & genomic medicine · 2019Article
- Evaluation of GALNT16 polymorphisms to breast cancer risk in Chinese population.Molecular genetics & genomic medicine · 2019Observational
- The distribution pattern of ERα expression, ESR1 genetic variation and expression of growth factor receptors: association with breast cancer prognosis in Russian patients treated with adjuvant tamoxifen.Clinical and experimental medicine · 2017Article
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9 authors.
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Abstract
Breast cancer is a heterogeneous disease which is influenced by genetic, environmental, and lifestyle factors. Genetic susceptibility is likely to be due to variants conferring more moderate risks. To identify susceptibility alleles, we conducted a case-control association study in 185 breast cancer cases and 199 controls in the Han population. We genotyped 14 tagging single nucleotide polymorphisms previously implicated in breast cancer using Sequenom MassARRAY SNP genotyping method and identified rs3734805 in the ESR1 gene and rs2048672 in the FLJ43663 gene were associated with breast cancer risk. Allele "C" of rs3734805 was associated with increased breast cancer progression by χ (2) test and additive model analysis (OR = 1.36; 95% CI, 1.01-1.82; p = 0.042). Using recessive model analysis, we found that genotype "GG" of rs2048672 was the protective genotype during breast cancer progression (OR = 0.55; 95% CI, 0.32-0.95; p = 0.029). Our results provide additional insights into the opposing roles of the ESR1 and FLJ43663 genes in breast cancer onset and progression.
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