ArticleMolecular psychiatry2014
Life events: a complex role in the timing of suicidal behavior among depressed patients.
Article in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder: A Systematic Review of Cross-Diagnostic Studies.Frontiers in psychiatry · 2021Pooled it
- Risk Factors for Suicidality in Patients With Schizophrenia: A Systematic Review, Meta-analysis, and Meta-regression of 96 Studies.Schizophrenia bulletin · 2018Pooled it
- Childhood adversity, adulthood adversity and suicidal ideation in Chinese patients with major depressive disorder: in line with stress sensitization.European archives of psychiatry and clinical neuroscience · 2022Trial
- Suicidal ideation among medical and surgical inpatients at South Gondar Public Hospitals, Northwest Ethiopia, 2023: a multicenter institution-based cross-sectional study.European archives of psychiatry and clinical neuroscience · 2026Article
- Suicide Risk and Living Alone With Depression or Anxiety.JAMA network open · 2025Article
- Omics Approaches to Investigate the Pathogenesis of Suicide.Biological psychiatry · 2024Review
- Occurrence and characteristics of suicidal ideation in psychiatrically healthy individuals based on ecological momentary assessment.Molecular psychiatry · 2024Article
- Investigating risk of self-harm and suicide on anniversaries after bereavement by suicide and other causes: a Danish population-based self-controlled case series study.Epidemiology and psychiatric sciences · 2023Article
- The mediating effect of distress tolerance on the relationship between stressful life events and suicide risk in patients with major depressive disorder.BMC psychiatry · 2023Article
- Using the stress-vulnerability model to better understand suicide in prison populations.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2023Article
- Living Alone and Suicide Risk in the United States, 2008‒2019.American journal of public health · 2022Article
- Highly variable suicidal ideation: a phenotypic marker for stress induced suicide risk.Molecular psychiatry · 2021Article
- Identifying Neurobiological Underpinnings of Two Suicidal Subtypes.Journal of psychiatry and brain science · 2021Article
- Borderline personality disorder and prior suicide attempts define a severity gradient among hospitalized adolescent suicide attempters.BMC psychiatry · 2020Article
- Personal Life Events-A Promising Dimension for Psychiatry in Electronic Health Records.JAMA psychiatry · 2020Article
- Do Suicide Attempts of Mood Disorder Patients Directly Increase the Risk for a Reattempt?Frontiers in psychiatry · 2020Article
- Recent Stressful Life Events in Euthymic Major Depressive Disorder Patients: Sociodemographic and Clinical Characteristics.Frontiers in psychiatry · 2020Article
- Changes In Plasma NPY, IL-1β And Hypocretin In People Who Died By Suicide.Neuropsychiatric disease and treatment · 2019Article
- Suicidal ideation and behavior in institutions of higher learning: A latent class analysis.Journal of psychiatric research · 2017Article
- Toward fine-grained phenotyping of suicidal behavior: the role of suicidal subtypes.Molecular psychiatry · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Suicidal behavior is often conceptualized as a response to overwhelming stress. Our model posits that given a propensity for acting on suicidal urges, stressors such as life events or major depressive episodes (MDEs) determine the timing of suicidal acts. Depressed patients (n=415) were assessed prospectively for suicide attempts and suicide, life events and MDE over 2 years. Longitudinal data were divided into 1-month intervals characterized by MDE (yes/no), suicidal behavior (yes/no) and life event scores. Marginal logistic regression models were fit, with suicidal behavior as the response variable and MDE and life event score in either the same or previous month, respectively, as time-varying covariates. Among 7843 person-months, 33% had MDE and 73% had life events. MDE increased the risk for suicidal behavior (odds ratio (OR)=4.83, P⩽0.0001). Life event scores were unrelated to the timing of suicidal behavior (OR=1.06 per 100 point increase, P=0.32), even during a MDE (OR=1.12, P=0.15). However, among those without borderline personality disorder (BPD), both health- and work-related life events were key precipitants, as was recurrent MDE, with a 13-fold effect. The relationship of life events to suicidal behavior among those with BPD was more complex. Recurrent MDE was a robust precipitant for suicidal behavior, regardless of BPD comorbidity. The specific nature of life events is key to understanding the timing of suicidal behavior. Given unanticipated results regarding the role of BPD and study limitations, these findings require replication. Of note, that MDE, a treatable risk factor, strongly predicts suicidal behaviors is cause for hope.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.