ArticleMolecular psychiatry2014
Specificity of psychosis, mania and major depression in a contemporary family study.
Article in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of psychopathology in bipolar high-risk offspring and siblings: a meta-analysis.European child & adolescent psychiatry · 2018Pooled it
- The effect of sleep-wake behaviors on the onset of mania in youth: A computational model.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology.Molecular psychiatry · 2026Article
- A Critical Overview of the Validity of the Current Concept of Bipolar Disorder.Journal of personalized medicine · 2025Review
- Identifying genetic differences between bipolar disorder and major depression through multiple genome-wide association analyses.The British journal of psychiatry : the journal of mental science · 2025Article
- Identifying genetic differences between bipolar disorder and major depression through multiple GWAS.medRxiv : the preprint server for health sciences · 2024Article
- The Nature of the Familial Risk for Psychosis in Bipolar Disorder.Schizophrenia bulletin · 2024Article
- Examining the Relationships between the Incidence of Infectious Diseases and Mood Disorders: An Analysis of Data from the Global Burden of Disease Studies, 1990-2019.Diseases (Basel, Switzerland) · 2023Article
- Family environment and polygenic risk in the bipolar high-risk context.JCPP advances · 2023Article
- Does circadian dysrhythmia drive the switch into high- or low-activation states in bipolar I disorder?Bipolar disorders · 2023Review
- Psychotic features, particularly mood incongruence, as a hallmark of severity of bipolar I disorder.International journal of bipolar disorders · 2022Article
- Article
- Familial risk of psychosis in obsessive-compulsive disorder: Impact on clinical characteristics, comorbidity and treatment response.Journal of psychiatric research · 2022Article
- Environmental factors in offspring of parents with mood disorders and their role in parent-child transmission: findings from a 14-year prospective high-risk study.International journal of bipolar disorders · 2022Article
- Associations Between Maternal Post-traumatic Stress Disorder and Traumatic Events With Child Psychopathology: Results From a Prospective Longitudinal Study.Frontiers in psychiatry · 2021Article
- Comorbidity and patterns of familial aggregation in attention-deficit/hyperactivity disorder and bipolar disorder in a family study of affective and anxiety spectrum disorders.Journal of psychiatric research · 2020Article
- On the diagnostic and neurobiological origins of bipolar disorder.Translational psychiatry · 2020Review
- The structure of mania: An overview of factorial analysis studies.European psychiatry : the journal of the Association of European Psychiatrists · 2020Review
- Characteristics of youth with reported family history of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort.Schizophrenia research · 2020Article
- Shedding light on the onset of psychiatric illness: looking through a developmental lens.Evidence-based mental health · 2019Article
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Abstract
There has been increasing attention to the subgroups of mood disorders and their boundaries with other mental disorders, particularly psychoses. The goals of the present paper were (1) to assess the familial aggregation and co-aggregation patterns of the full spectrum of mood disorders (that is, bipolar, schizoaffective (SAF), major depression) based on contemporary diagnostic criteria; and (2) to evaluate the familial specificity of the major subgroups of mood disorders, including psychotic, manic and major depressive episodes (MDEs). The sample included 293 patients with a lifetime diagnosis of SAF disorder, bipolar disorder and major depressive disorder (MDD), 110 orthopedic controls, and 1734 adult first-degree relatives. The diagnostic assignment was based on all available information, including direct diagnostic interviews, family history reports and medical records. Our findings revealed specificity of the familial aggregation of psychosis (odds ratio (OR)=2.9, confidence interval (CI): 1.1-7.7), mania (OR=6.4, CI: 2.2-18.7) and MDEs (OR=2.0, CI: 1.5-2.7) but not hypomania (OR=1.3, CI: 0.5-3.6). There was no evidence for cross-transmission of mania and MDEs (OR=.7, CI:.5-1.1), psychosis and mania (OR=1.0, CI:.4-2.7) or psychosis and MDEs (OR=1.0, CI:.7-1.4). The strong familial specificity of psychotic, manic and MDEs in this largest controlled contemporary family study challenges the growing assertion that the major types of mood disorders are manifestations of a common underlying diathesis.
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