ArticleThe Journal of investigative dermatology2014
Fibronectin peptides that bind PDGF-BB enhance survival of cells and tissue under stress.
Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 39 citations in OpenAlex.
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- FN9-10ELP, an ECM-Mimetic Fusion Protein, Protects Human Mesenchymal Stem Cells from Etoposide-Induced Senescence.International journal of molecular sciences · 2025Article
- Expression and Biological Activity Analysis of Recombinant Fibronectin3 Protein inBiotech (Basel (Switzerland)) · 2025Article
- Effects of Topography and PDGF on the Response of Corneal Keratocytes to Fibronectin-Coated Surfaces.Journal of functional biomaterials · 2023Article
- Amnion bilayer for dressing and graft replacement for delayed grafting of full-thickness burns; A study in a rat model.PloS one · 2022Article
- Extracellular matrix-derived peptides in tissue remodeling and fibrosis.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
- Involvement of Integrin-Activating Peptides Derived from Tenascin-C in Cancer Aggression and New Anticancer Strategy Using the Fibronectin-Derived Integrin-Inactivating Peptide.Molecules (Basel, Switzerland) · 2020Review
- Article
- Assembly of fibronectin fibrils selectively attenuates platelet-derived growth factor-induced intracellular calcium release in fibroblasts.The Journal of biological chemistry · 2018Article
- Vasoactive effect of fibronectin-derived epiviosamine-1 and related peptides in quiescent and stress models.Microcirculation (New York, N.Y. : 1994) · 2017Article
- Phosphoinositide 3-kinase/protein kinase B/periostin mediated platelet-derived growth factor-induced cell proliferation and extracellular matrix production in lupus nephritis.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- IL-4 impairs wound healing potential in the skin by repressing fibronectin expression.The Journal of allergy and clinical immunology · 2017Article
- A Small Chimeric Fibronectin Fragment Accelerates Dermal Wound Repair in Diabetic Mice.Advances in wound care · 2016Article
- Fibronectin Interaction and Enhancement of Growth Factors: Importance for Wound Healing.Advances in wound care · 2015Review
- A fibronectin peptide redirects PDGF-BB/PDGFR complexes to macropinocytosis-like internalization and augments PDGF-BB survival signals.The Journal of investigative dermatology · 2014Article
- A fibronectin-derived cell survival peptide belongs to a new class of epiviosamines.The Journal of investigative dermatology · 2014Article
- Fibronectin at select sites binds multiple growth factors and enhances their activity: expansion of the collaborative ECM-GF paradigm.The Journal of investigative dermatology · 2014Review
- Fibronectin peptides that bind PDGF-BB enhance survival of cells and tissue under stress.The Journal of investigative dermatology · 2014Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Stressors after injury from a multitude of factors can lead to cell death. We have identified four fibronectin (FN) peptides: two from the first FN type III repeat (FNIII1), one from the 13th FN type III repeat (FNIII13), and one from FN variable region (IIICS), which when tethered to a surface acted as platelet-derived growth factor-BB (PDGF-BB) enhancers to promote cell survival. One of the FNIII1 peptides and its smallest (14-mer) bioactive form (P12) were also active in solution. Specifically, P12 bound PDGF-BB (KD=200 nM), enhanced adult human dermal fibroblast (AHDF) survival under serum starvation, oxidative or endoplasmic reticulum stressors, and limited burn-injury progression in a rat hot comb model. Furthermore, P12 inhibited endoplasmic reticulum stress-induced c-Jun N-terminal kinase (JNK) activation. Although many growth factors have been found to bind FN directly or indirectly, here we identify peptide sequences of growth factor-binding sites in FN. The finding of these peptides further delineated how the extracellular matrix protein FN can support cell survival. As the peptide P12 is active in either soluble form or tethered to a substrate, it will have multifactorial uses as a bioactive peptide by itself or in tissue engineering.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.