ArticlePediatric research2014
Chlorhexidine inhibits L1 cell adhesion molecule-mediated neurite outgrowth in vitro.
Article in Pediatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Aqueous chlorhexidine 1% versus 2% for neonatal skin antisepsis: a randomised non-inferiority trial.Archives of disease in childhood. Fetal and neonatal edition · 2021Trial
- Choline supplementation mitigates effects of bilirubin in cerebellar granule neurons in vitro.Pediatric research · 2024Article
- Hypothermia increases cold-inducible protein expression and improves cerebellar-dependent learning after hypoxia ischemia in the neonatal rat.Pediatric research · 2023Article
- Myelin toxicity of chlorhexidine in zebrafish larvae.Pediatric research · 2023Article
- Assessment of Alcohol Exposure From Alcohol-Based Disinfectants Among Premature Infants in Neonatal Incubators in Japan.JAMA network open · 2023Article
- Neonatal hypoxia ischemia redistributes L1 cell adhesion molecule into rat cerebellar lipid rafts.Pediatric research · 2022Article
- Bilirubin inhibits lipid raft dependent functions of L1 cell adhesion molecule in rat pup cerebellar granule neurons.Pediatric research · 2021Article
- Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression.BMC cancer · 2019Article
- Chlorhexidine baths in preterm infants - are we there yet?Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Article
- Trends in Chlorhexidine Use in US Neonatal Intensive Care Units: Results From a Follow-Up National Survey.Infection control and hospital epidemiology · 2016Article
- Toluene disruption of the functions of L1 cell adhesion molecule at concentrations associated with occupational exposures.Pediatric research · 2016Article
- Antiseptic use in the neonatal intensive care unit - a dilemma in clinical practice: An evidence based review.World journal of clinical pediatrics · 2016Review
- Chlorhexidine gluconate for antisepsis in preterm neonates: A review of safety and efficacy.Pediatric dermatologyReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundChlorhexidine is a skin disinfectant that reduces skin and mucous membrane bacterial colonization and inhibits organism growth. Despite numerous studies assessing chlorhexidine safety in term infants, residual concerns have limited its use in hospitalized neonates, especially low-birth-weight preterm infants. The aim of this study was to assess the potential neurotoxicity of chlorhexidine on the developing central nervous system using a well-established in vitro model of neurite outgrowth that includes laminin and L1 cell adhesion molecule (L1) as neurite outgrowth-promoting substrates.
methodsCerebellar granule neurons are plated on poly L-lysine, L1, or laminin. Chlorhexidine, hexachlorophene, or their excipients are added to the media. Neurons are grown for 24 h, fixed, and neurite length is measured.
resultsChlorhexidine significantly reduced the length of neurites grown on L1 but not on laminin. Chlorhexidine concentrations as low as 125 ng/ml statistically significantly reduced neurite length on L1. Hexachlorophene did not affect neurite length.
conclusionChlorhexidine at concentrations detected in the blood following topical applications in preterm infants specifically inhibited L1-mediated neurite outgrowth of cerebellar granule neurons. It is now vital to determine whether the blood-brain barrier is permeable to chlorhexidine in preterm infants.
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