ArticleVirchows Archiv : an international journal of pathology2013
A panel of four immunohistochemical markers (CK7, CK20, TTF-1, and p63) allows accurate diagnosis of primary and metastatic lung carcinoma on biopsy specimens.
Article in Virchows Archiv : an international journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 42 citations in OpenAlex.
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- Solitary pulmonary metastasis with cystic airspaces in colon cancer: A rare case report.Open life sciences · 2025Article
- [Inaugural Scalp Metastasis of Pulmonary Squamous Cell Carcinoma: A Rare Case Report and Literature Review].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Review
- Multimodal treatment of oligometastatic non-small cell lung cancer.BMJ case reports · 2023Article
- Lymph node and bone metastasis of pulmonary intestinal adenocarcinoma: A case report.Oncology letters · 2023Article
- The Complementary Role of PET to Pathology in Differentiating the Primary Origin of a Malignant Skin Nodule from Liver or Lung.Nuclear medicine and molecular imaging · 2023Article
- Anti-CK7/CK20 Immunohistochemistry Did Not Associate with the Metastatic Site in TTF-1-Negative Lung Cancer.Diagnostics (Basel, Switzerland) · 2022Article
- p63 expression in human tumors and normal tissues: a tissue microarray study on 10,200 tumors.Biomarker research · 2021Article
- Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning.Science advances · 2020Article
- A Neural Network Framework for Predicting the Tissue-of-Origin of 15 Common Cancer Types Based on RNA-Seq Data.Frontiers in bioengineering and biotechnology · 2020Article
- Patterns and risks of postoperative recurrence in completely resected EGFR-mutant non-small cell lung cancer: prognostic significance of routine immunohistochemical markers.Translational lung cancer research · 2019Article
- A qualitative transcriptional signature for the histological reclassification of lung squamous cell carcinomas and adenocarcinomas.BMC genomics · 2019Article
- Subtyping Lung Cancer Using DNA Methylation in Liquid Biopsies.Journal of clinical medicine · 2019Article
- Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2019Article
- Radiomic signature as a diagnostic factor for histologic subtype classification of non-small cell lung cancer.European radiology · 2018Article
- Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer.Bioscience reports · 2017Article
- A prediction model for distinguishing lung squamous cell carcinoma from adenocarcinoma.Oncotarget · 2017Article
- Pulmonary enteric adenocarcinoma with pancreatic metastasis: A case report.Oncology letters · 2017Article
- Use of Diagnostic Tests in Advanced Non-Small Cell Lung Cancer.Journal of the advanced practitioner in oncology · 2017Review
- Trefoil factor 3 as a novel biomarker to distinguish between adenocarcinoma and squamous cell carcinoma.Medicine · 2015Article
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6 authors at 1 institution in 1 country.
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Abstract
Accurate classification of lung cancer, as well as the differentiation between primary and metastatic carcinoma to the lung, mostly performed on biopsy or fine needle aspiration specimens, is critical for decisions on therapy and for determining prognosis. The limited amount of biopsy material available for morphological assessment has stimulated attempts to improve diagnostic accuracy through the use of immunohistochemistry (IHC), but an optimal IHC diagnostic algorithm has not been firmly established. We evaluated, on a retrospective series of biopsy specimens, the performance of a four-antibody IHC panel for accurate subclassification of non-small cell lung carcinoma (NSCLC) and for identification of metastatic carcinoma. Tumor morphology was assessed and IHC for CK7, CK20, TTF-1, and p63 was performed according to a two-step algorithm. Matched resection specimens served as gold standard and were compared with the corresponding biopsy. Of 443 biopsy specimens studied, 325 were diagnosed as primary carcinoma of the lung, 198 (44.7 %) as adenocarcinoma, 9 (2 %) as possibly adenosquamous carcinoma, 127 (28.7 %) as squamous cell carcinoma, and 40 (9 %) as NSCLC not further classifiable. Ten cases (2.3 %) were classified as adenocarcinoma of unknown origin and 58 (13 %) as metastasis. Importantly, of the primary lung adenocarcinomas, 35 (17.7 %) had been considered on clinical grounds as a metastasis from a previously diagnosed primary tumor. Of the 55 cases submitted to surgical resection in 47 (85.5 %) the biopsy diagnosis was confirmed, revealing substantial agreement (κ value = 0.757). Our two-step approach allows for accurate subclassification of NSCLC and also to distinguish between primary lung adenocarcinoma and metastasis, notably of colorectal adenocarcinoma, with crucial implications for appropriate patient management.
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