ArticleEMBO reports2013
Nucleosome sliding by Chd1 does not require rigid coupling between DNA-binding and ATPase domains.
Article in EMBO reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- A competitive regulatory mechanism of the Chd1 remodeler is integral to distorting nucleosomal DNA.Nature structural & molecular biology · 2025Article
- Regulation of DNA translocation of chromatin remodeler enzyme Chd1 by exit DNA unwrapping.Life metabolism · 2025Article
- Structural basis of human CHD1 nucleosome recruitment and pausing.Molecular cell · 2025Article
- Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease.Genes & development · 2021Review
- Biophysics of Chromatin Remodeling.Annual review of biophysics · 2021Review
- The Role of Non-Catalytic Domains of Hrp3 in Nucleosome Remodeling.International journal of molecular sciences · 2021Article
- Autoinhibitory elements of the Chd1 remodeler block initiation of twist defects by destabilizing the ATPase motor on the nucleosome.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Chd1 Chromatin Remodeler Shifts Nucleosomal DNA Bidirectionally as a Monomer.Molecular cell · 2017Article
- The Sequence of Nucleosomal DNA Modulates Sliding by the Chd1 Chromatin Remodeler.Journal of molecular biology · 2017Article
- Interdomain Communication of the Chd1 Chromatin Remodeler across the DNA Gyres of the Nucleosome.Molecular cell · 2017Article
- The Chd1 chromatin remodeler can sense both entry and exit sides of the nucleosome.Nucleic acids research · 2016Article
- Structure of chromatin remodeler Swi2/Snf2 in the resting state.Nature structural & molecular biology · 2016Article
- Molecular Mechanism of Mot1, a TATA-binding Protein (TBP)-DNA Dissociating Enzyme.The Journal of biological chemistry · 2016Article
- Mechanisms of ATP-Dependent Chromatin Remodeling Motors.Annual review of biophysics · 2016Review
- Sequence-targeted nucleosome sliding in vivo by a hybrid Chd1 chromatin remodeler.Genome research · 2016Article
- A nucleotide-driven switch regulates flanking DNA length sensing by a dimeric chromatin remodeler.Molecular cell · 2015Article
- Remodelling without a power stroke.EMBO reports · 2013Article
- No need for a power stroke in ISWI-mediated nucleosome sliding.EMBO reports · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chromatin remodellers are ATP-dependent motor proteins that physically reposition and reorganize nucleosomes. Chd1 and Iswi-type remodellers possess a DNA-binding domain (DBD) needed for efficient nucleosome mobilization; however, it has not been clear how this domain physically contributes to remodelling. Here we show that the Chd1 DBD promotes nucleosome sliding simply by tethering the remodeller to nucleosome substrates. Nucleosome sliding activity was largely resistant to increasing length and flexibility of the linker connecting the DBD and ATPase motor, arguing that the ATPase motor does not shift DNA onto the nucleosome by pulling on the DBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.