Evidence map›Paper›PMID 24126718›Full record

ReviewCurrent opinion in infectious diseases2013

Update on mucormycosis pathogenesis.

Ashraf S Ibrahim, Dimitrios P Kontoyiannis

Abstract readReview
In one paragraph

Review in Current opinion in infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Article
  2. Fatal Rhinocerebral Mucormycosis andCase reports in medicine · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Mucormycosis and Hearing: A Hospital-Based Study.International archives of otorhinolaryngology · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Role of the putativeMicrobial cell (Graz, Austria) · 2025
    Article
  11. Article
  12. Article
  13. Rare case of a chronic rhinocerebral mucormycosis.Medical mycology case reports · 2024
    Article
  14. Article
  15. IntegratingCurrent research in microbial sciences · 2024
    Article
  16. Article
  17. Osteoarticular Mycoses.Clinical microbiology reviews · 2022
    Review
  18. COVID-19 and Fungal Diseases.Antibiotics (Basel, Switzerland) · 2022
    Review
  19. Article
  20. A rare case of cutaneous mucormycosis in the forearm: A case report.International journal of surgery case reports · 2022
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ashraf S IbrahimaDivision of Infectious Diseases, Harbor-University of California Los Angeles Medical Center bSt. John's Cardiovascular Research Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance cDavid Geffen School of Medicine at UCLA, Los Angeles, California dDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Dimitrios P Kontoyiannis

Funding

Novel Toxins and Receptors in Mucormycosis Pathogenesis and TreatmentR01AI063503 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI IBRAHIM, ASHRAF S. · 2006 to 2025
$7.3M
NIAID NIH HHS R01 AI063503
6 · The paper itself

Abstract

purpose of reviewMucormycosis is an increasingly common fungal infection with unacceptably high mortality. The recent sequencing genome projects of Mucorales and the development of gene manipulation have enabled significant advances in understanding the pathogenesis of mucormycosis. Therefore, we review the pathogenesis of mucormycosis and highlight potential development of novel diagnostic and therapeutic modalities against this lethal disease. RECENT

findingsMuch of the work has been focused on the role of iron uptake in the virulence of Mucorales. Additionally, host receptors and fungal ligands involved in the process of tissue invasion as well as sporangiospore size and sex loci and their contribution to virulence of Mucorales are discussed. Finally, the role of innate and adaptive immunity in protection against Mucorales and new evidence about drug-induced apoptosis in these fungi are discussed. SUMMARY: Recent discoveries introduce several potentially novel diagnostic and therapeutic modalities, which are likely to improve management and outcome for mucormycosis. Future preclinical and clinical research is warranted to develop these diagnostic and therapeutic strategies.

Indexed as

Antifungal AgentsAzolesHost-Pathogen InteractionsHumansImmunocompromised HostIronMucoralesMucormycosisRisk FactorsAntifungal AgentsAzolesIron

Identifiers

PMID24126718
PMCPMC4081484

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.