ArticleInfection and immunity2014
MBL2 variations and malaria susceptibility in Indian populations.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Influence of the presence of mannose-binding lectin polymorphisms on the occurrence of leishmaniasis: a systematic review and meta-analysis.Anais brasileiros de dermatologiaPooled it
- Association of mannose binding lectin with chronic obstructive pulmonary disease susceptibility and its clinical outcomes.Molecular biology reports · 2023Article
- Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Unveiling the Sugary Secrets ofFrontiers in microbiology · 2021Review
- The ambiguous role of mannose-binding lectin (MBL) in human immunity.Open medicine (Warsaw, Poland) · 2021Review
- Exploring association between MBL2 gene polymorphisms and the occurrence of clinical blackwater fever through a case-control study in Congolese children.Malaria journal · 2020Article
- Genetic association of MBL-2 gene polymorphisms with Filarial chyluria.Bioinformation · 2019Article
- Impact of SNPs interplay across the locus ofCell & bioscience · 2019Article
- Genetic and Phenotypic Screening of Mannose-Binding Lectin in Relation to Risk of Recurrent Vulvovaginal Infections in Women of North India: A Prospective Cohort Study.Frontiers in microbiology · 2017Article
- HLA Class I and II alleles, heterozygosity and HLA-KIR interactions are associated with rates of genital HSV shedding and lesions.Genes and immunity · 2016Article
- A comprehensive in silico analysis of non-synonymous and regulatory SNPs of human MBL2 gene.SpringerPlus · 2016Article
- Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis.PLoS neglected tropical diseases · 2015Article
- Article
- Role of mannose-binding lectin deficiency in HIV-1 and schistosoma infections in a rural adult population in Zimbabwe.PloS one · 2015Article
- MBL-2 polymorphisms (codon 54 and Y-221X) and low MBL levels are associated with susceptibility to multi organ dysfunction in P. falciparum malaria in Odisha, India.Frontiers in microbiology · 2015Article
- Extreme high prevalence of a defective mannose-binding lectin (MBL2) genotype in native South American West Andean populations.PloS one · 2014Article
- Mannose binding lectin and susceptibility to rheumatoid arthritis in Brazilian patients and their relatives.PloS one · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human mannose-binding lectin (MBL) encoded by the MBL2 gene is a pattern recognition protein and has been associated with many infectious diseases, including malaria. We sought to investigate the contribution of functional MBL2 gene variations to Plasmodium falciparum malaria in well-defined cases and in matched controls. We resequenced the 8.7 kb of the entire MBL2 gene in 434 individuals clinically classified with malaria from regions of India where malaria is endemic. The study cohort included 176 patients with severe malaria, 101 patients with mild malaria, and 157 ethnically matched asymptomatic individuals. In addition, 830 individuals from 32 socially, linguistically, and geographically diverse endogamous populations of India were investigated for the distribution of functional MBL2 variants. The MBL2 -221C (X) allelic variant is associated with increased risk of malaria (mild malaria odds ratio [OR] = 1.9, corrected P value [P(Corr)] = 0.0036; severe malaria OR = 1.6, P(Corr) = 0.02). The exon1 variants MBL2*B (severe malaria OR = 2.1, P(Corr) = 0.036; mild versus severe malaria OR = 2.5, P(Corr) = 0.039) and MBL2*C (mild versus severe malaria OR = 5.4, P(Corr) = 0.045) increased the odds of having malaria. The exon1 MBL2*D/*B/*C variant increased the risk for severe malaria (OR = 3.4, P(Corr) = 0.000045). The frequencies of low MBL haplotypes were significantly higher in severe malaria (14.2%) compared to mild malaria (7.9%) and asymptomatic (3.8%). The MBL2*LYPA haplotypes confer protection, whereas MBL2*LXPA increases the malaria risk. Our findings in Indian populations demonstrate that MBL2 functional variants are strongly associated with malaria and infection severity.
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