ArticleEuropean archives of psychiatry and clinical neuroscience2014
Symptom changes in five dimensions of the Positive and Negative Syndrome Scale in refractory psychosis.
Article in European archives of psychiatry and clinical neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Disentangling the Relationships Between the Clinical Symptoms of Schizophrenia Spectrum Disorders and Theory of Mind: A Meta-analysis.Schizophrenia bulletin · 2023Pooled it
- Clinical outcomes in individuals at clinical high risk of psychosis who do not transition to psychosis: a meta-analysis.Epidemiology and psychiatric sciences · 2022Pooled it
- Predicting functional remission after antipsychotic discontinuation: a real-world study in schizophrenia.Psychological medicine · 2026Article
- COSMIN systematic review and meta-analysis of the measurement properties of the Positive and Negative Syndrome Scale (PANSS).EClinicalMedicine · 2025Article
- COSMIN review of the PANSS Marder factor solution and other factor models in people with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Developing prediction models for symptom severity around the time of discharge from a tertiary-care program for treatment-resistant psychosis.Frontiers in psychiatry · 2023Article
- Validation of natural language processing methods capturing semantic incoherence in the speech of patients with non-affective psychosis.Frontiers in psychiatry · 2023Article
- Antipsychotic prescribing patterns on admission to and at discharge from a tertiary care program for treatment-resistant psychosis.PloS one · 2018Article
- Focus on psychosis.Dialogues in clinical neuroscience · 2015Review
- New aspects of cognition domains and psychopathological measures in psychiatry.European archives of psychiatry and clinical neuroscience · 2014Article
- Symptom dimensions of the psychotic symptom rating scales in psychosis: a multisite study.Schizophrenia bulletin · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Refractory psychosis units currently have little information regarding which symptoms profiles should be expected to respond to treatment. In the current study, we provide this information using structural equation modeling of Positive and Negative Syndrome Scale (PANSS) ratings at admission and discharge on a sample of 610 patients admitted to a treatment refractory psychosis program at a Canadian tertiary care unit between 1990 and 2011. The hypothesized five-dimensional structure of the PANSS fit the data well at both admission and discharge, and the latent variable scores are reported as a function of symptom dimension and diagnostic category. The results suggest that, overall, positive symptoms (POS) responded to treatment better than all other symptoms dimensions, but for the schizoaffective and bipolar groups, greater response on POS was observed relative to the schizophrenia and major depression groups. The major depression group showed the most improvement on negative symptoms and emotional distress, and the bipolar group showed the most improvement on disorganization. Schizophrenia was distinct from schizoaffective disorder in showing reduced treatment response on all symptom dimensions. These results can assist refractory psychosis units by providing information on how PANSS symptom dimensions respond to treatment and how this depends on diagnostic category.
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