ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Aversive learning in adolescents: modulation by amygdala-prefrontal and amygdala-hippocampal connectivity and neuroticism.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Regulation of PVT-CeA Circuit in Deoxynivalenol-Induced Anorexia and Aversive-Like Emotions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Impact of behavioral inhibitory control and startle reactivity to uncertain threat on youth suicide risk.Psychophysiology · 2025Article
- Superior frontal gyrus and middle temporal gyrus connectivity mediates the relationship between neuroticism and thought suppression.Brain imaging and behavior · 2022Article
- Childhood Emotional Neglect and Cardiovascular Disease: A Narrative Review.Frontiers in cardiovascular medicine · 2022Review
- Trait neuroticism and emotion neurocircuitry: Functional magnetic resonance imaging evidence for a failure in emotion regulation.Development and psychopathology · 2019Article
- Chronic harsh parenting and anxiety associations with fear circuitry function in healthy adolescents: A preliminary study.Biological psychology · 2019Article
- Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood.Scientific reports · 2019Article
- Neuroticism Modulates the Functional Connectivity From Amygdala to Frontal Networks in Females When Avoiding Emotional Negative Pictures.Frontiers in behavioral neuroscience · 2019Article
- Predicting personality from network-based resting-state functional connectivity.Brain structure & function · 2018Article
- Genetic and environmental influences on the codevelopment among borderline personality disorder traits, major depression symptoms, and substance use disorder symptoms from adolescence to young adulthood.Development and psychopathology · 2018Article
- Is Our Self Related to Personality? A Neuropsychodynamic Model.Frontiers in human neuroscience · 2018Article
- Article
- Prefrontal-Amygdala Connectivity and State Anxiety during Fear Extinction Recall in Adolescents.Frontiers in human neuroscience · 2017Article
- Extraversion and neuroticism related to the resting-state effective connectivity of amygdala.Scientific reports · 2016Article
- Extinction learning in childhood anxiety disorders, obsessive compulsive disorder and post-traumatic stress disorder: implications for treatment.Expert review of neurotherapeutics · 2016Review
- Neuroticism and extraversion moderate neural responses and effective connectivity during appetitive conditioning.Human brain mapping · 2016Article
- Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders.Biological psychiatry · 2016Review
- Neuroimaging of Fear-Associated Learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Forming competing fear learning and extinction memories in adolescence makes fear difficult to inhibit.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Intrinsic Amygdala Functional Connectivity in Youth With Bipolar I Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2015Article
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Authors and funding
19 authors.
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Abstract
Neuroticism involves a tendency for enhanced emotional and cognitive processing of negative affective stimuli and a propensity to worry and be anxious. It is known that this trait modulates fear learning and the activation of brain regions involved in it such as the amygdala, hippocampus, and prefrontal cortex and their connectivity. Thirty-nine (21 female) 14-year-old healthy adolescents participated in functional magnetic resonance imaging (fMRI) of aversive pavlovian differential delay conditioning. An unpleasant sound served as unconditioned stimulus (US) and pictures of neutral male faces as conditioned stimuli (CS+ followed by the US in 50% of the cases; CS- never followed by the US). During acquisition (CS+/- differentiation), higher levels of neuroticism were associated with a stronger interaction between the right amygdala and the right hippocampus as well as the right amygdala and prefrontal cortical regions, specifically ventromedial prefrontal cortex, dorsolateral prefrontal cortex, and anterior cingulate cortex. The association of stronger conditionability of fear and connectivity of brain regions related to consolidation of fear associations and neuroticism points to underlying mechanisms of the enhanced propensity for anxiety disorders in highly neurotic participants. This is especially important in adolescence, a vulnerable time for the onset of mental disorders such as anxiety disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.