ReviewDer Nervenarzt2014
[Nalmefene: a novel pharmacotherapeutic option for alcoholism].
Review in Der Nervenarzt, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Weak evidence on nalmefene creates dilemmas for clinicians and poses questions for regulators and researchers.Addiction (Abingdon, England) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Relapses into alcoholism are becoming more frequent even after long-term psychotherapy and social therapy. Previous evidence-based pharmacotherapy was limited to administration of acamprosate and the opioid antagonist naltrexone. Both forms of therapy have not become well established in Germany. The European Medicine Agency (EMA) has now approved a further opioid antagonist, nalmefene which is an antagonist of the µ-opioid receptor just as naltrexon and is also a partial agonist of kappa receptors. The preclinical and clinical investigations carried out with nalmefene are presented. It seems to be interesting that in the therapy studies relevant to approval, nalmefene was not administered for support of abstinence but as an"as needed"medication for reduction of drink volume.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.