Evidence map›Paper›PMID 24125554›Full record

ReviewMolecular microbiology2013

Mannosylation in Candida albicans: role in cell wall function and immune recognition.

Rebecca A Hall, Neil A R Gow

Open access · hybridAbstract readReview
In one paragraph

Review in Molecular microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 199 citations in OpenAlex.

  1. Review
  2. Article
  3. Insights on molecular drivers of phenotypic plasticity in Candidozyma auris.World journal of microbiology & biotechnology · 2026
    Review
  4. Article
  5. Loss of Fgr41 inInfection and immunity · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Glycan microarray analysis ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Echinocandin Adaptation inJournal of fungi (Basel, Switzerland) · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rebecca A HallAberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Aberdeen, AB252ZD, UK.
Neil A R Gow
University of Aberdeen · GB

Funding

Wellcome TrustWellcome Trust 075470Wellcome Trust 080088Wellcome Trust 086827Wellcome Trust 097377Wellcome Trust 099215
6 · The paper itself

Abstract

The fungal cell wall is a dynamic organelle required for cell shape, protection against the environment and, in pathogenic species, recognition by the innate immune system. The outer layer of the cell wall is comprised of glycosylated mannoproteins with the majority of these post-translational modifications being the addition of O- and N-linked mannosides. These polysaccharides are exposed on the outer surface of the fungal cell wall and are, therefore, the first point of contact between the fungus and the host immune system. This review focuses on O- and N-linked mannan biosynthesis in the fungal pathogen Candida albicans and highlights new insights gained from the characterization of mannosylation mutants into the role of these cell wall components in host-fungus interactions. In addition, we discuss the use of fungal mannan as a diagnostic marker of fungal disease.

Indexed as

AnimalsCandida albicansCandidiasisCell WallFungal ProteinsGlycosylationHumansImmunity, InnateMannansMannosidesMembrane GlycoproteinsProtein Processing, Post-TranslationalVirulence FactorsFungal ProteinsMannansmannoproteinsMannosidesMembrane GlycoproteinsVirulence Factors

Identifiers

PMID24125554
PMCPMC4112839
OpenAlexW2127458887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.