ArticleJournal of diabetes science and technology2013
Dose accuracy and injection force of different insulin glargine pens.
Article in Journal of diabetes science and technology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- A review of reusable insulin pens and features of TouStar-a new reusable pen with a dedicated cartridge.Diabetology & metabolic syndrome · 2021Review
- Half-Unit Insulin Pens: Disease Management in Patients With Diabetes Who Are Sensitive to Insulin.Journal of diabetes science and technology · 2017Review
- Open-Label, Randomized, Two-Way, Crossover Study Assessing the Bioequivalence of the Liquid Formulation versus the Freeze-Dried Formulation of Recombinant Human FSH and Recombinant Human LH in a Fixed 2:1 Combination (PergoverisFrontiers in endocrinology · 2017Article
- Boluses in Insulin Therapy.Journal of diabetes science and technology · 2017Review
- Development of devices for self-injection: using tribological analysis to optimize injection force.Medical devices (Auckland, N.Z.) · 2016Article
- Clinical Use and Evaluation of Insulin Pens.Journal of diabetes science and technology · 2015Article
- Functional Evaluation of the Reusable JuniorSTAR® Half-Unit Insulin Pen.Journal of diabetes science and technology · 2015Article
- Dialing torque preferences of people with diabetes when using insulin pens: a pilot study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDose accuracy and injection force, representing key parameters of insulin pens, were determined for three pens delivering insulin glargine-based copies, Pen Royale (WR) and DispoPen (WD) for Glaritus® (Wockhardt) and GanLee Pen (GL) for Basalin® (Gan & Lee), compared with pens of the originator, ClikSTAR® (CS) and SoloSTAR® (SS) for Lantus® (Sanofi).
methodsUsing the weighing procedure recommended by DIN EN ISO 11608-1:2000, dose accuracy was evaluated based on nonrandomized delivery of low (5 U), mid (30 U), and high (60 U) dosage levels. Injection force was measured by dispensing the maximum dose of insulin (60 U for the GL, WR, and WD; 80 U for the SS and CS) at dose speeds of 6 and 10 U/s.
resultsAll tested pens delivered comparable average doses within the DIN EN ISO 11608-1:2000 limits at all dosage levels. The GL revealed a higher coefficient of variation (CV) at 5 U, and the WR and WD had higher CVs at all dosage levels compared with the CS and SS. Injection force was higher for the WR, WD, and GL compared with the CS and SS at both dose speeds. In contrast to the CS and SS with an end-of-content feature, doses exceeding the remaining insulin could be dialed with the WR, GL, and WD and, apparently, dispensed with the WD.
conclusionsAll pens fulfilled the dose accuracy requirements defined by DIN EN ISO 11608-1:2000 standards at all three dosage levels, with the WR, WD, and GL showing higher dosage variability and injection force compared with the SS and CS. Thus, the devices that deliver insulin glargine copies show different performance characteristics compared with the originator.
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