ArticlePloS one2013
MLVA genotyping of Brucella melitensis and Brucella abortus isolates from different animal species and humans and identification of Brucella suis vaccine strain S2 from cattle in China.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Extracellular vesicle microRNA signature as a highly accurate diagnostic biomarker for human brucellosis.Frontiers in cellular and infection microbiology · 2026Article
- Machine learning based on pangenome-wide association studies reveals the impact of host source on the zoonotic potential of closely related bacterial pathogens.Communications biology · 2025Article
- Molecular Epidemiology ofVeterinary sciences · 2025Article
- Case report: diagnosis of neurobrucellosis in a non-endemic area child using metagenomic next-generation sequencing.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- In silico MLVA Analysis of Brucella melitensis from Human and Livestock in Iran.Current microbiology · 2025Article
- Molecular epidemiology ofFrontiers in microbiology · 2025Article
- Whole-genome sequencing for genetic diversity analysis of IranianOne health (Amsterdam, Netherlands) · 2023Article
- Brucella spp. distribution, hosting ruminants from Greece, applying various molecular identification techniques.BMC veterinary research · 2022Article
- Identification and molecular characterization of Brucella abortus and Brucella melitensis isolated from milk in cattle in Azerbaijan.BMC veterinary research · 2022Article
- Molecular characteristics of Brucella melitensis isolates from humans in Qinghai Province, China.Infectious diseases of poverty · 2021Article
- Whole-genome sequencing of roughEmerging microbes & infections · 2020Article
- Cell membrane components of Brucella melitensis play important roles in the resistance of low-level rifampicin.PLoS neglected tropical diseases · 2020Article
- Genetic variation of Brucella isolates at strain level in Egypt.Veterinary medicine and science · 2020Article
- First isolation, identification and genetic characterization of Brucella abortus biovar 3 from dairy cattle in Bangladesh.Veterinary medicine and science · 2019Article
- Genomic Characterization Provides New Insights for Detailed Phage- Resistant Mechanism forFrontiers in microbiology · 2019Article
- Global evolution and phylogeography of Brucella melitensis strains.BMC genomics · 2018Article
- Genetic polymorphisms identify in species/biovars of Brucella isolated in China between 1953 and 2013 by MLST.BMC microbiology · 2018Article
- Molecular Investigation of the Transmission Pattern ofFrontiers in veterinary science · 2018Article
- Caprine brucellosis: A historically neglected disease with significant impact on public health.PLoS neglected tropical diseases · 2017Review
- Multi-locus variable-number tandem repeat analysis of Chinese Brucella strains isolated from 1953 to 2013.Infectious diseases of poverty · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In China, brucellosis is an endemic disease and the main sources of brucellosis in animals and humans are infected sheep, cattle and swine. Brucella melitensis (biovars 1 and 3) is the predominant species, associated with sporadic cases and outbreak in humans. Isolates of B. abortus, primarily biovars 1 and 3, and B. suis biovars 1 and 3 are also associated with sporadic human brucellosis. In this study, the genetic profiles of B. melitensis and B. abortus isolates from humans and animals were analyzed and compared by multi-locus variable-number tandem-repeat analysis (MLVA). Among the B. melitensis isolates, the majority (74/82) belonged to MLVA8 genotype 42, clustering in the 'East Mediterranean' group. Two B. melitensis biovar 1 genotype 47 isolates, belonging to the 'Americas' group, were recovered; both were from the Himalayan blue sheep (Pseudois nayaur, a wild animal). The majority of B. abortus isolates (51/70) were biovar 3, genotype 36. Ten B. suis biovar 1 field isolates, including seven outbreak isolates recovered from a cattle farm in Inner Mongolia, were genetically indistinguishable from the vaccine strain S2, based on MLVA cluster analysis. MLVA analysis provided important information for epidemiological trace-back. To the best of our knowledge, this is the first report to associate Brucella cross-infection with the vaccine strain S2 based on molecular comparison of recovered isolates to the vaccine strain. MLVA typing could be an essential assay to improve brucellosis surveillance and control programs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.