ReviewFrontiers in human neuroscience2013
Self-referential processing, rumination, and cortical midline structures in major depression.
Review in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 8 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
182 citing papers in PubMed, 8 syntheses or guidelines pooled it, 359 citations in OpenAlex.
- Nitrous oxide for the treatment of depression: a systematic review and meta-analysis.EBioMedicine · 2025Pooled it
- Resting-state network alterations in depression: a comprehensive meta-analysis of functional connectivity.Psychological medicine · 2025Pooled it
- Convergent abnormality in the subgenual anterior cingulate cortex in insomnia disorder: A revisited neuroimaging meta-analysis of 39 studies.Sleep medicine reviews · 2023Pooled it
- Psychophysiological responses to psychological stress exposure and neural correlates in adults with mental disorders: a scoping review.Frontiers in psychiatry · 2023Pooled it
- Structural, functional, and metabolic signatures of postpartum depression: A systematic review.Frontiers in psychiatry · 2022Pooled it
- Identification of Common Neural Circuit Disruptions in Emotional Processing Across Psychiatric Disorders.The American journal of psychiatry · 2020Pooled it
- Mindfulness-based cognitive therapy for bipolar disorder: A systematic review.Journal of affective disorders · 2018Pooled it
- A systematic review of relations between resting-state functional-MRI and treatment response in major depressive disorder.Journal of affective disorders · 2015Pooled it
- Investigating the neural and behavioral correlates of the stress-rumination link in healthy humans by modulating the left Dorsolateral Prefrontal Cortex using Theta Burst Stimulation.Cognitive, affective & behavioral neuroscience · 2025Trial
- Network effects of Stanford Neuromodulation Therapy (SNT) in treatment-resistant major depressive disorder: a randomized, controlled trial.Translational psychiatry · 2023Trial
- Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020Trial
- Trial
- Neural correlates of rumination in adolescents with remitted major depressive disorder and healthy controls.Cognitive, affective & behavioral neuroscience · 2017Trial
- Combined rTMS treatment targeting the Anterior Cingulate and the Temporal Cortex for the Treatment of Chronic Tinnitus.Scientific reports · 2015Trial
- Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study.PloS one · 2015Trial
- Distinct and shared therapeutic neural mechanisms of mindfulness-based and social support stress reduction groups in adults with autism spectrum disorder.Journal of psychiatry & neuroscience : JPNTrial
- Maternal Depression, Childhood Resting-State Brain Connectivity, and Adolescent Depression During the COVID-19 Outbreak.Developmental psychobiology · 2026Article
- Neural markers of working memory and emotional regulation are predictors of future depression severity in at risk young adults: a replication study.Molecular psychiatry · 2026Article
- Is Richard Baxter's Melancholia Still Relevant Today?: Comparative Network Structures of Depressive Symptoms in Asian Individuals With Guilt-Rich and Guilt-Free Depression.Psychiatry investigation · 2026Article
122 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depression is associated with a bias toward negative emotional processing and increased self-focus, i.e., the process by which one engages in self-referential processing. The increased self-focus in depression is suggested to be of a persistent, repetitive and self-critical nature, and is conceptualized as ruminative brooding. The role of the medial prefrontal cortex in self-referential processing has been previously emphasized in acute major depression. There is increasing evidence that self-referential processing as well as the cortical midline structures play a major role in the development, course, and treatment response of major depressive disorder. However, the links between self-referential processing, rumination, and the cortical midline structures in depression are still poorly understood. Here, we reviewed brain imaging studies in depressed patients and healthy subjects that have examined these links. Self-referential processing in major depression seems associated with abnormally increased activity of the anterior cortical midline structures. Abnormal interactions between the lateralized task-positive network, and the midline cortical structures of the default mode network, as well as the emotional response network, may underlie the pervasiveness of ruminative brooding. Furthermore, targeting this maladaptive form of rumination and its underlying neural correlates may be key for effective treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.