ArticleWorld journal of gastroenterology2013
Effect of early enteral combined with parenteral nutrition in patients undergoing pancreaticoduodenectomy.
Article in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03150615 (Effect of Enteral Nutrition on Delayed Gastric Emptying After Pancreaticoduodenectomy), which is not on this map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Enteral Nutrition on Delayed Gastric Emptying After Pancreaticoduodenectomy: A Prospective, Randomized Controlled Trial
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Postoperative nutritional support after pancreaticoduodenectomy in adults.The Cochrane database of systematic reviews · 2025Pooled it
- Pooled it
- ACG Clinical Guideline: Nutrition Therapy in the Adult Hospitalized Patient.The American journal of gastroenterology · 2016Guideline
- Risks and Benefits of Feeding Enterostomy Creation During Minimally Invasive Esophagectomy: A Propensity-Weighted Analysis Using the Japanese National Clinical Database.Annals of gastroenterological surgery · 2026Article
- Development and external validation of nomogram associated with gastroparesis syndrome after subtotal gastrectomy depending on random forest and traditional model: does robotic surgery have advantages?Journal of robotic surgery · 2025Article
- Effects of early enteral and parenteral nutrition support combined with "Internet + nursing service" on quality of life and complications in patients with malignant obstructive jaundice after percutaneous hepatic puncture biliary drainage.Frontiers in surgery · 2025Article
- Short- and Long-Term Outcomes of Neoadjuvant Chemoradiotherapy Followed by Pancreatoduodenectomy in Elderly Patients with Resectable and Borderline Resectable Pancreatic Cancer: A Retrospective Study.Journal of clinical medicine · 2024Article
- A clinical observational study on the application of enhanced recovery after laparoscopic pancreaticoduodenectomy.Frontiers in surgery · 2022Article
- Nutritional assessment and surgical outcomes in very elderly patients undergoing pancreaticoduodenectomy: a retrospective study.Surgery today · 2021Article
- Effect of early and delay starting of enteral feeding in post-pancreaticoduodenectomy patients.Annals of hepato-biliary-pancreatic surgery · 2019Article
- Pancreaticoduodenectomy for duodenal papilla carcinoma: A single-centre 9-year retrospective study of 112 patients with long-term follow-up.World journal of gastroenterology · 2017Article
- Early enteral nutrition vs parenteral nutrition following pancreaticoduodenectomy: Experience from a single center.World journal of gastroenterology · 2016Article
- Early combined parenteral and enteral nutrition for pancreaticoduodenectomy - Retrospective cohort analysis.Annals of medicine and surgery (2012) · 2016Article
- Review
- Feeding jejunostomy tube placement in patients undergoing pancreaticoduodenectomy: an ongoing dilemma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of early enteral nutrition (EEN) combined with parenteral nutritional support in patients undergoing pancreaticoduodenectomy (PD).
methodsFrom January 2006, all patients were given EEN combined with parenteral nutrition (PN) (EEN/PN group, n = 107), while patients prior to this date were given total parenteral nutrition (TPN) (TPN group, n = 67). Venous blood samples were obtained for a nutrition-associated assessment and liver function tests on the day before surgery and 6 d after surgery. The assessment of clinical outcome was based on postoperative complications. Follow-up for infectious and noninfectious complications was carried out for 30 d after hospital discharge. Readmission within 30 d after discharge was also recorded.
resultsCompared with the TPN group, a significant decrease in prealbumin (PAB) (P = 0.023) was seen in the EEN/PN group. Total bilirubin (TB), direct bilirubin (DB) and lactate dehydrogenase (LDH) were significantly decreased on day 6 in the EEN/PN group (P = 0.006, 0.004 and 0.032, respectively). The rate of grade I complications, grade II complications and the length of postoperative hospital stay in the EEN/PN group were significantly decreased (P = 0.036, 0.028 and 0.021, respectively), and no hospital mortality was observed in our study. Compared with the TPN group (58.2%), the rate of infectious complications in the EEN/PN group (39.3%) was significantly decreased (P = 0.042). Eleven cases of delayed gastric emptying were noted in the TPN group, and 6 cases in the EEN/PN group. The rate of delayed gastric emptying and hyperglycemia was significantly reduced in the EEN/PN group (P = 0.031 and P = 0.040, respectively).
conclusionEarly enteral combined with PN can greatly improve liver function, reduce infectious complications and delayed gastric emptying, and shorten postoperative hospital stay in patients undergoing PD.
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