Observational studyPediatric pulmonology2014
Early childhood wheezing is associated with lower lung function in cystic fibrosis.
Observational study in Pediatric pulmonology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Prevalence and Determinants of Wheezing and Bronchodilatation in Children With Cystic Fibrosis: A Retrospective Cohort Study.Frontiers in pediatrics · 2022Article
- Hyperinflation is associated with increased respiratory rate and is a more sensitive measure of cystic fibrosis lung disease during infancy compared to forced expiratory measures.Pediatric pulmonology · 2021Article
- Epidemiologic Study of Cystic Fibrosis: 25 years of observational research.Pediatric pulmonology · 2021Review
- Is Impulse Oscillometry System a Useful Method for the Evaluation and Follow-Up of Patients with Cystic Fibrosis?Pediatric allergy, immunology, and pulmonology · 2021Article
- Asthma in Cystic Fibrosis: Definitions and Implications of This Overlap Syndrome.Current allergy and asthma reports · 2021Review
- Wheezing in Infancy: An Overview of Recent Literature.Current allergy and asthma reports · 2017Review
- Socioeconomic Status, Smoke Exposure, and Health Outcomes in Young Children With Cystic Fibrosis.Pediatrics · 2017Article
- Early Childhood Risk Factors for Decreased FEV1 at Age Six to Seven Years in Young Children with Cystic Fibrosis.Annals of the American Thoracic Society · 2015Observational
- Validation of computerized wheeze detection in young infants during the first months of life.BMC pediatrics · 2014Article
- Cat and dog exposure and respiratory morbidities in cystic fibrosis.The Journal of pediatrics · 2014Article
- Clinical and laboratory profile of children with Cystic Fibrosis: Experience of a tertiary care center in Pakistan.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo study the association between wheezing in children with cystic fibrosis (CF) and lung function in later life.
methodsWe used data from the Epidemiologic Study of CF, a longitudinal observational study from 1994 to 2005. Wheezing phenotypes were defined as: no wheezing in the first 6 years of life (NW), transient wheezing (TW; wheezing <3 years old, but no wheezing after 3), late wheezing (LW; wheezing only after age 3 years), and persistent wheezing (PW; wheezing both before and after age 3 years). A linear regression model was developed predicting the best forced expiratory volume in 1 sec (FEV1 ) at age 6 or 7 years (6 to <8) for each wheezing phenotype.
resultsA total of 1302 children met the cohort inclusion criteria; 61% of the cohort had wheezing in the first 6 years of life. A history of any wheezing in the first 6 years of life was associated with a significantly lower FEV1 at 6 to <8 years compared to children with NW. The FEV1 of children with NW at age 6 to <8 years was 104% predicted, whereas the mean FEV1 in TW, LW, and PW groups was 98%, 100%, and 96% predicted, respectively (P < 0.05 compared to NW).
conclusionsChildhood wheezing in CF is common and is associated with lower lung function at age 6 to <8 years. Our results identify a clinical feature in early childhood CF associated with lower lung function in later life.
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