ReviewAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2013
The XY gene hypothesis of psychosis: origins and current status.
Review in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Hearing loss impacts gray and white matter across the lifespan: Systematic review, meta-analysis and meta-regression.NeuroImage · 2021Pooled it
- The role of plasma oxytocin in early-onset schizophrenia: implications for disease severity and early intervention.BMC psychiatry · 2026Article
- Reassessing Asymmetry Reduction in Psychosis: Cingulate Folding and Gyrification Covariance in Patients with Auditory Hallucinations.Schizophrenia bulletin · 2026Article
- Exploring causal mechanisms of psychosis risk.Neuroscience and biobehavioral reviews · 2024Review
- Y chromosome is moving out of sex determination shadow.Cell & bioscience · 2022Review
- Effect of Electro-Acupuncture on Lateralization of the Human Swallowing Motor Cortex Excitability by Navigation-Transcranial Magnetic Stimulation-Electromyography.Frontiers in behavioral neuroscience · 2022Article
- Sex-Related Differences in White Matter Asymmetry and Its Implications for Verbal Working Memory in Psychosis High-Risk State.Frontiers in psychiatry · 2021Article
- Global and Specific Cortical Volume Asymmetries in Individuals With Psychosis Risk Syndrome and Schizophrenia: A Mixed Cross-sectional and Longitudinal Perspective.Schizophrenia bulletin · 2020Article
- Neuropsychiatric Aspects in Men with Klinefelter Syndrome.Endocrine, metabolic & immune disorders drug targets · 2019Review
- The Sex Chromosome Hypothesis of Schizophrenia: Alive, Dead, or Forgotten? A Commentary and Review.Molecular neuropsychiatry · 2018Article
- Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia.Nature neuroscience · 2016Article
- Why sex differences in schizophrenia?Journal of translational neuroscience · 2016Article
- Spatial sexual dimorphism of X and Y homolog gene expression in the human central nervous system during early male development.Biology of sex differences · 2016Article
- Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective Disorders.EBioMedicine · 2015Article
- Epigenomic and transcriptomic signatures of a Klinefelter syndrome (47,XXY) karyotype in the brain.Epigenetics · 2014Article
- Left brain, right brain: facts and fantasies.PLoS biology · 2014Article
- Abnormal asymmetry of brain connectivity in schizophrenia.Frontiers in human neuroscience · 2014Review
- Schizophrenia and cortical blindness: protective effects and implications for language.Frontiers in human neuroscience · 2014Article
- Globularity and language-readiness: generating new predictions by expanding the set of genes of interest.Frontiers in psychology · 2014Article
- Multivariate neuroanatomical classification of cognitive subtypes in schizophrenia: a support vector machine learning approach.NeuroImage. Clinical · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Sex differences in psychosis and their interaction with laterality (systematic departures from 50:50 left-right symmetry across the antero-posterior neural axis) are reviewed in the context of the X-Y gene hypothesis. Aspects of laterality (handedness/cerebral asymmetry/the torque) predict (1) verbal and non-verbal ability in childhood and across adult life and (2) anatomical, physiological, and linguistic variation relating to psychosis. Neuropsychological and MRI evidence from individuals with sex chromosome aneuploidies indicates that laterality is associated with an X-Y homologous gene pair. Within each mammalian species the complement of such X-Y gene pairs reflects their potential to account for taxon-specific sexual dimorphisms. As a consequence of the mechanism of meiotic suppression of unpaired chromosomes <MSUC> such X-Y gene pairs generate epigenetic variation around a species defining motif that is carried to the zygote with potential to initiate embryonic gene expression in XX or XY format. The Protocadherin11XY (PCDH11XY) gene pair in Xq21.3/Yp11.2 in probable coordination with a gene or genes within PAR2 (the second pseudo-autosomal region) is the prime candidate in relation to cerebral asymmetry and psychosis in Homo sapiens. The lately-described pattern of sequence variation associated with psychosis on the autosomes may reflect a component of the human genome's adjustment to selective pressures generated by the sexually dimorphic mate recognition system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.