ArticleApplied and environmental microbiology2014
Resistance of Bacillus subtilis spore DNA to lethal ionizing radiation damage relies primarily on spore core components and DNA repair, with minor effects of oxygen radical detoxification.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 83 citations in OpenAlex.
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- New Thoughts on an Old Topic: Secrets of Bacterial Spore Resistance Slowly Being Revealed.Microbiology and molecular biology reviews : MMBR · 2023Review
- Sporicidal mechanism of the combination of ortho-phthalaldehyde and benzyldimethyldodecylammonium chloride as a disinfectant against the Bacillus subtilis spores.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- The smallest space miners: principles of space biomining.Extremophiles : life under extreme conditions · 2022Review
- What's new and notable in bacterial spore killing!World journal of microbiology & biotechnology · 2021Review
- Spore Germination of the Obligate BiotrophFrontiers in microbiology · 2021Article
- Effects of Heavy Ion Particle Irradiation on Spore Germination ofLife (Basel, Switzerland) · 2020Article
- Phylogenetic Analysis ofMicroorganisms · 2020Article
- Article
- Article
- Role of DNA Repair and Protective Components in Bacillus subtilis Spore Resistance to Inactivation by 400-nm-Wavelength Blue Light.Applied and environmental microbiology · 2018Article
- A Standard Method To Inactivate Bacillus anthracis Spores to Sterility via Gamma Irradiation.Applied and environmental microbiology · 2018Article
- Article
- Single-cell analysis reveals individual spore responses to simulated space vacuum.NPJ microgravity · 2018Article
- Evolution with a seed bank: The population genetic consequences of microbial dormancy.Evolutionary applications · 2018Review
- Experimental studies addressing the longevity of Bacillus subtilis spores - The first data from a 500-year experiment.PloS one · 2018Article
- Activation and inactivation of Bacillus pumilus spores by kiloelectron volt X-ray irradiation.PloS one · 2017Article
- Fighting Ebola with novel spore decontamination technologies for the military.Frontiers in microbiology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The roles of various core components, including α/β/γ-type small acid-soluble spore proteins (SASP), dipicolinic acid (DPA), core water content, and DNA repair by apurinic/apyrimidinic (AP) endonucleases or nonhomologous end joining (NHEJ), in Bacillus subtilis spore resistance to different types of ionizing radiation including X rays, protons, and high-energy charged iron ions have been studied. Spores deficient in DNA repair by NHEJ or AP endonucleases, the oxidative stress response, or protection by major α/β-type SASP, DPA, and decreased core water content were significantly more sensitive to ionizing radiation than wild-type spores, with highest sensitivity to high-energy-charged iron ions. DNA repair via NHEJ and AP endonucleases appears to be the most important mechanism for spore resistance to ionizing radiation, whereas oxygen radical detoxification via the MrgA-mediated oxidative stress response or KatX catalase activity plays only a very minor role. Synergistic radioprotective effects of α/β-type but not γ-type SASP were also identified, indicating that α/β-type SASP's binding to spore DNA is important in preventing DNA damage due to reactive oxygen species generated by ionizing radiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.