ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Increased level of E protein activity during invariant NKT development promotes differentiation of invariant NKT2 and invariant NKT17 subsets.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- E protein-driven iNKT subset modulation shapes early immune responses during influenza A virus infection.American journal of respiratory cell and molecular biology · 2026Article
- T Cell Development: From T-Lineage Specification to Intrathymic Maturation.Advances in experimental medicine and biology · 2025Review
- Helix-Loop-Helix Proteins in Adaptive Immune Development.Frontiers in immunology · 2022Review
- Development of αβ T Cells with Innate Functions.Advances in experimental medicine and biology · 2022Article
- ILC Differentiation in the Thymus.Advances in experimental medicine and biology · 2022Article
- Augmenting E Protein Activity Impairs cDC2 Differentiation at the Pre-cDC Stage.Frontiers in immunology · 2020Article
- Development of Type 2 Innate Lymphoid Cells Is Selectively Inhibited by Sustained E Protein Activity.ImmunoHorizons · 2019Article
- PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision.Cellular & molecular immunology · 2019Article
- The Protein Phosphatase Shp1 Regulates Invariant NKT Cell Effector Differentiation Independently of TCR and Slam Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- The ins and outs of type I iNKT cell development.Molecular immunology · 2019Review
- Id Proteins Suppress E2A-Driven Invariant Natural Killer T Cell Development prior to TCR Selection.Frontiers in immunology · 2018Article
- Id2 Collaborates with Id3 To Suppress Invariant NKT and Innate-like Tumors.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Downregulation of E Protein Activity Augments an ILC2 Differentiation Program in the Thymus.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-γ production in iNKT cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Development of invariant natural killer T cells.Current opinion in immunology · 2016Review
- CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity.Journal of immunology research · 2016Review
- Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signaling.Scientific reports · 2015Article
- Review
- Orchestration of invariant natural killer T cell development by E and Id proteins.Critical reviews in immunology · 2015Review
- ID'ing innate and innate-like lymphoid cells.Immunological reviews · 2014Review
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Authors and funding
8 authors.
Funding
Abstract
E protein transcription factors and their natural inhibitors, Id proteins, play critical and complex roles during lymphoid development. In this article, we report that partial maintenance of E protein activity during positive selection results in a change in the cell fate determination of developing iNKT cells, with a block in the development of iNKT1 cells and a parallel increase in the iNKT2 and iNKT17 subsets. Because the expression levels of the transcription factors that drive these alternative functional fates (GATA-3, RORγT, T-bet, and Runx-3) are not altered, our results suggest that E protein activity controls a novel checkpoint that regulates the number of iNKT precursors that choose each fate.
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Registered trials
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