ArticleMagnetic resonance in medicine2014
In vivo detection of citrate in brain tumors by 1H magnetic resonance spectroscopy at 3T.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Optimization of the flip angles of narrow-band editing pulses in J-difference edited MRS of lactate at 3T.Magnetic resonance in medicine · 2024Article
- Ex vivo NMR metabolomics approach using cerebrospinal fluid for the diagnosis of primary CNS lymphoma: Correlation with MR imaging characteristics.Cancer medicine · 2023Article
- The influence of cystathionine on neurochemical quantification in brain tumor in vivo MR spectroscopy.Magnetic resonance in medicine · 2022Article
- Detection of 2-hydroxyglutarate in brain tumors by triple-refocusing MR spectroscopy at 3T in vivo.Magnetic resonance in medicine · 2017Article
- Application of Single Voxel 1H Magnetic Resonance Spectroscopy in Hepatic Benign and Malignant Lesions.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Citrate concentrations increase with hypoperfusion in pediatric diffuse intrinsic pontine glioma.Journal of neuro-oncology · 2015Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo test whether citrate is elevated in adult patients with gliomas using (1)H magnetic resonance spectroscopy (MRS) at 3T in vivo.
methodsThirty-four adult patients were enrolled in the study, including six subjects with glioblastomas, eight subjects with astrocytomas (World Health Organization grade 3, n = 5; grade 2, n = 3), and 20 subjects with oligodendrogliomas (grade 3, n = 5; grade 2, n = 15). Five healthy volunteers were studied for baseline citrate data. Single-voxel localized spectra were collected with point-resolved spectroscopy (PRESS) echo times of 35 and 97 ms and were analyzed with LCModel software using numerically calculated basis spectra that included the effects of the PRESS radiofrequency and gradient pulses.
resultsCitrate was not measurable by MRS in healthy brain but was detected in tumor patients at both echo times. The citrate concentration was estimated to be as high as 1.8 mM with reference to water at 42 M, with Cramér-Rao lower bounds (CRLB) as low as 5%. The mean citrate level was 0.7 ± 0.4 mM (mean ± SD, n = 32) with a median CRLB of ∼12%. No correlation was identified between citrate concentration and tumor grade or histological type.
conclusionCitrate was increased in the majority of gliomas in adult patients. The elevated citrate in our data indicates an altered metabolic state of tumor relative to healthy brain.
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