Evidence map›Paper›PMID 24123296›Full record

ReviewHepatology (Baltimore, Md.)2014

Desmoplastic stroma and cholangiocarcinoma: clinical implications and therapeutic targeting.

Alphonse E Sirica, Gregory J Gores

Registry-linked trialAbstract readReview
In one paragraph

Review in Hepatology (Baltimore, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06893380 (A Multicenter Phase 1b/2 Trial Investigating the Efficacy and Toxicity of the Combination of Gemcitabine, Cisplatin, Nab-Paclitaxel, and Tislelizumab in Treatment Naïve Patients With Unresectable, Locally Advanced, or Metastatic BTC), which is not on this map. Cited by 116 papers.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06893380 recruitingnot on this mapstarted 2024, after this paper: background citation

A Multicenter Phase 1b/2 Trial Investigating the Efficacy and Toxicity of the Combination of Gemcitabine, Cisplatin, Nab-Paclitaxel, and Tislelizumab in Treatment Naïve Patients With Unresectable, Locally Advanced, or Metastatic BTC

Typeobservational_patient_registrySponsorCHA UniversityRan2024 to 2026Enrolled61ConditionsLocally Advanced Biliary Tract Cancers, Metastatic Biliary Tract CancersArmsGemcitabine, Cisplatin, Nab-paclitaxel, and Tislelizumab.
3 · Its place in the literature

Who cites it

116 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Cholangiocarcinoma 2026: status quo, unmet needs and priorities.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Next-Generation Hydrogels for Biliary Organoid Engineering.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alphonse E SiricaDivision of Cellular and Molecular Pathogenesis, Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA.
Gregory J Gores

Funding

ALTERED GROWTH FACTOR PATHWAYS IN BILLIARY CANCERR01CA083650 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SIRICA, ALPHONSE E · 2000 to 2017
$4.4M
Mechanisms of Carcinogenesis in Biliary EpitheliaR01DK059427 · NIDDK · MAYO CLINIC ROCHESTER · PI GORES, GREGORY J. · 2001 to 2016
$4.3M
HEPATIC OVAL CELLS IN CULTURE AND IN VIVOR01CA039225 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SIRICA, ALPHONSE E · 1986 to 2011
$3.1M
Mechanisms of Carcinogenesis in Biliary EpitheliaR56DK059427 · NIDDK · MAYO CLINIC ROCHESTER · PI GORES, GREGORY J. · 2006 to 2006
$243k
NCI NIH HHS CA39225NCI NIH HHS R01 CA039225NCI NIH HHS R01 CA083650NCI NIH HHS R01 CA83650NIDDK NIH HHS DK59427NIDDK NIH HHS R01 DK059427NIDDK NIH HHS R56 DK059427
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ActinsAnimalsBile Duct NeoplasmsBile Ducts, IntrahepaticCholangiocarcinomaFibroblastsHumansMolecular Targeted TherapyPrognosisACTA2 protein, humanActins

Identifiers

PMID24123296
PMCPMC3975806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.