ArticleEukaryotic cell2013
Parasexuality and ploidy change in Candida tropicalis.
Article in Eukaryotic cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Review
- Structural Diversity and Differential Natural Pairings of MAT1-1-1 and MAT1-2-1 Proteins Essential for Sexual Reproduction inInternational journal of molecular sciences · 2026Article
- Article
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- Ploidy plasticity drives fungal resistance to azoles used in agriculture and clinics.PLoS biology · 2025Article
- Three-Dimensional Structural Heteromorphs of Mating-Type Proteins inJournal of fungi (Basel, Switzerland) · 2025Article
- Mutations and Differential Transcription of Mating-Type and Pheromone Receptor Genes inBiology · 2024Article
- Genetic Diversity of Human Fungal Pathogens.Current clinical microbiology reports · 2023Article
- On the evolution of variation in sexual reproduction through the prism of eukaryotic microbes.Proceedings of the National Academy of Sciences of the United States of America · 2023Review
- Raman Spectroscopy of OralInternational journal of molecular sciences · 2022Article
- Biosynthesis of aliphatic plastic monomers with amino residues inFrontiers in bioengineering and biotechnology · 2022Article
- Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples.PLoS pathogens · 2021Article
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- Is Natural Population ofFrontiers in cellular and infection microbiology · 2021Review
- Host-Induced Genome Instability Rapidly Generates Phenotypic Variation across Candida albicans Strains and Ploidy States.mSphere · 2020Article
- Genomic evidence for a hybrid origin of the yeast opportunistic pathogen Candida albicans.BMC biology · 2020Article
- Single nucleus sequencing reveals evidence of inter-nucleus recombination in arbuscular mycorrhizal fungi.eLife · 2018Article
- Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A coupled process of same- and opposite-sex mating generates polyploidy and genetic diversity in Candida tropicalis.PLoS genetics · 2018Article
- Multilocus Sequence Typing Reveals a New Cluster of Closely RelatedFrontiers in microbiology · 2018Article
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5 authors.
Funding
Abstract
Candida species exhibit a variety of ploidy states and modes of sexual reproduction. Most species possess the requisite genes for sexual reproduction, recombination, and meiosis, yet only a few have been reported to undergo a complete sexual cycle including mating and sporulation. Candida albicans, the most studied Candida species and a prevalent human fungal pathogen, completes its sexual cycle via a parasexual process of concerted chromosome loss rather than a conventional meiosis. In this study, we examine ploidy changes in Candida tropicalis, a closely related species to C. albicans that was recently revealed to undergo sexual mating. C. tropicalis diploid cells mate to form tetraploid cells, and we show that these can be induced to undergo chromosome loss to regenerate diploid forms by growth on sorbose medium. The diploid products are themselves mating competent, thereby establishing a parasexual cycle in this species for the first time. Extended incubation (>120 generations) of C. tropicalis tetraploid cells under rich culture conditions also resulted in instability of the tetraploid form and a gradual reduction in ploidy back to the diploid state. The fitness levels of C. tropicalis diploid and tetraploid cells were compared, and diploid cells exhibited increased fitness relative to tetraploid cells in vitro, despite diploid and tetraploid cells having similar doubling times. Collectively, these experiments demonstrate distinct pathways by which a parasexual cycle can occur in C. tropicalis and indicate that nonmeiotic mechanisms drive ploidy changes in this prevalent human pathogen.
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