ArticleJournal of cellular physiology2014
Angiogenin stimulates ribosomal RNA transcription by epigenetic activation of the ribosomal DNA promoter.
Article in Journal of cellular physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The Potential of Angiogenin as a Serum Biomarker for Diseases: Systematic Review and Meta-Analysis.Disease markers · 2018Pooled it
- Article
- Tailoring the stress response of human skin cells by substantially limiting the nuclear localization of angiogenin.Heliyon · 2024Article
- Epigenetics in the formation of pathological aggregates in amyotrophic lateral sclerosis.Frontiers in molecular neuroscience · 2024Review
- Translation dysregulation in neurodegenerative diseases: a focus on ALS.Molecular neurodegeneration · 2023Review
- Review
- Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival.British journal of cancer · 2022Article
- Characterization and Function of the Interaction of Angiogenin With Alpha-Actinin 2.Frontiers in molecular biosciences · 2022Article
- Angiogenin and Copper Crossing in Wound Healing.International journal of molecular sciences · 2021Review
- Angiogenin and tRNA fragments in Parkinson's disease and neurodegeneration.Acta pharmacologica Sinica · 2020Review
- Chemosensitization of prostate cancer stem cells in mice by angiogenin and plexin-B2 inhibitors.Communications biology · 2020Article
- Functional roles of the human ribonuclease A superfamily in RNA metabolism and membrane receptor biology.Molecular aspects of medicine · 2019Review
- Angiogenin generates specific stress-induced tRNA halves and is not involved in tRF-3-mediated gene silencing.The Journal of biological chemistry · 2019Article
- Angiogenin activates the astrocytic Nrf2/antioxidant-response element pathway and thereby protects murine neurons from oxidative stress.The Journal of biological chemistry · 2019Article
- Surveillance of Tumour Development: The Relationship Between Tumour-Associated RNAs and Ribonucleases.Frontiers in pharmacology · 2019Review
- Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs.Molecular neurobiology · 2018Article
- Angiogenin negatively regulates the expression of basic fibroblast growth factor (bFGF) and inhibits bFGF promoter activity.International journal of clinical and experimental pathology · 2018Article
- RNA biology of angiogenin: Current state and perspectives.RNA biology · 2017Review
- Molecular basis for the autonomous promotion of cell proliferation by angiogenin.Nucleic acids research · 2017Article
- A Novel Extrinsic Pathway for the Unfolded Protein Response in the Kidney.Journal of the American Society of Nephrology : JASN · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Angiogenin (ANG) undergoes nuclear translocation and promotes ribosomal RNA (rRNA) transcription thereby enhancing cell growth and proliferation. However, the mode of action of ANG in stimulating rRNA transcription is unclear. Here, we show that ANG enhances the formation of RNA polymerase I (Pol I) pre-initiation complex at the ribosomal DNA (rDNA) promoter. ANG binds at the upstream control element (UCE) of the promoter and enhances promoter occupancy of RNA Pol I as well as the selectivity factor SL1 components TAFI 48 and TAFI 110. We also show that ANG increases the number of actively transcribing rDNA by epigenetic activation through promoter methylation and histone modification. ANG binds to histone H3, inhibits H3K9 methylation, and activates H3K4 methylation as well as H4 acetylation at the rDNA promoter. These data suggest that one of the mechanisms by which ANG stimulates rRNA transcription is through an epigenetic activation of rDNA promoter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.