Evidence map›Paper›PMID 24122737›Full record

ArticleThe Laryngoscope2014

Complications of primary and revision functional endoscopic sinus surgery for chronic rhinosinusitis.

James G Krings, Dorina Kallogjeri, Andre Wineland, Kenneth G Nepple, Jay F Piccirillo, Anne E Getz

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in The Laryngoscope, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05145543 (Effect of Topically Administered Levobupivacaine- Fentanyl Versus Levobupivacaine- Dexamethasone Combination in the Control of Pain After Endoscopic Sinus Surgery), which is not on this map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05145543 phase2 / phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

Effect of Topically Administered Levobupivacaine- Fentanyl Versus Levobupivacaine- Dexamethasone Combination in the Control of Pain After Endoscopic Sinus Surgery: A Randomized Controlled Trial

TypeinterventionalSponsorAssiut UniversityRan2021 to 2022Enrolled80ConditionsEndoscopic Sinus Surgery, FentanylArmsSaline 0.9%, Levobupivacaine Hydrochloride, Fentanyl, Dexamethasone
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 214 citations in OpenAlex.

  1. Advanced Age in Sinus Surgery: Diminished Symptom Gains but Enhanced Surgical Durability in Chronic Rhinosinusitis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Pooled it
  2. Image guidance for endoscopic sinus surgery: systematic review and meta-analysis.Revista da Associacao Medica Brasileira (1992) · 2023
    Pooled it
  3. Article
  4. Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024).World journal of otorhinolaryngology - head and neck surgery · 2026
    Article
  5. Review
  6. Complications in Endoscopic Sinus Surgery: A TriNetX Network Analysis.International forum of allergy & rhinology · 2025
    Article
  7. Complications and Economic Burden of Surgery in Chronic Rhinosinusitis With Nasal Polyps: An Observational Cohort Study Using Swedish Register Data.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025
    Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. The use of biologics in patients suffering from chronic rhinosinusitis with nasal polyps - a 4-year real life observation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Observational
  19. Efficacy and safety of dupilumab in the treatment of CRSwNP in the real-life setting: a review of the literature.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Review
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

James G KringsDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri; Doris Duke Clinical Research Fellowship, Washington University School of Medicine; Stanford Medical Scholars Fellowship, Stanford University School of Medicine, Stanford, California, U.S.A.
Dorina Kallogjeri
Andre Wineland
Kenneth G Nepple
Jay F Piccirillo
Anne E Getz
Washington University in St. Louis · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
WASHINGTON UNIVERSITY CER MENTORED CAREER DEVELOPMENT AWARD KM1KM1CA156708 · NCI · WASHINGTON UNIVERSITY · PI FRASER, VICTORIA J. · 2010 to 2010
$2.5M
WASHINGTON UNIVERSITY COMPARATIVE EFFECTIVENESS ADMINISTRATIVE DATA REPOSITORYR24HS019455 · AHRQ · WASHINGTON UNIVERSITY · PI FRASER, VICTORIA J. · 2010 to 2010
$969k
AHRQ HHS R24 HS019455AHRQ HHS R24 HS19455NCATS NIH HHS UL1 TR000448NCI NIH HHS KM1 CA156708NCI NIH HHS KM1CA156708
6 · The paper itself

Abstract

objectives/hypothesisThe goal of this study was to determine the incidence of major complications following primary and revision functional endoscopic sinus surgery (FESS). In addition, this study aimed to determine factors associated with the occurrence of complications including patient and provider characteristics and the use of image guidance system (IGS) technology. STUDY

designRetrospective cohort analysis of California and Florida all-payer databases from 2005 to 2008.

methodsThe rates of major surgical complications (skull base, orbital, and hemorrhagic) after primary and revision FESS were calculated, and bivariate analyses were performed to investigate relationships of complications with demographic and clinical characteristics. A multivariate model was used to determine risk factors for the occurrence of major complications.

resultsAmong 78,944 primary FESS cases, 288 major complications were identified representing a complication rate of 0.36% (95% CI 0.32%-0.40%). The major complication rate following revision cases (n = 19; 0.46%) and primary cases (n = 288; 0.36%) was similar (OR = 1.26; 95% CI 0.79-2.00). Multivariate analysis showed that patients who were >40 years old, had a primary payer of Medicaid, had surgery involving the frontal sinus, or had image guidance during surgery were at higher risk for major complications.

conclusionThe rate of major complications (0.36%) associated with primary FESS is lower than earlier reports. The rate of major complications following revision FESS (0.46%) was found to be similar to primary cases. IGS, insurance status, age, and extent of surgery were found to be associated with an increased risk of major complications following FESS. LEVEL OF EVIDENCE: 2C.

Indexed as

AdolescentAdultAgedCaliforniaChildChronic DiseaseEndoscopyFemaleFloridaFollow-Up StudiesFrontal SinusHumansIncidenceMaleMiddle AgedOtorhinolaryngologic Surgical ProceduresChronic rhino sinusitiscomplicationsCSF leakdiplopiaendoscopic sinus surgeryepistaxishemorrhageorbital

Identifiers

PMID24122737
PMCPMC4357345
OpenAlexW2171745010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.