ArticlePathology oncology research : POR2014
Clinical course of central neurocytoma with malignant transformation-an indication for craniospinal irradiation.
Article in Pathology oncology research : POR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- The clinical spectrum of central neurocytomas ranges from benign to leptomeningeal disseminating disease: a single institutional surgical series of 33 patients.Frontiers in surgery · 2025Article
- Molecular and clinical characterization of atypical central neurocytomas: implications for diagnosis and treatment strategies.Discover oncology · 2024Article
- Whole-exome sequencing reveals genetic variants that may play a role in neurocytomas.Journal of neuro-oncology · 2024Article
- Rare Neuronal, Glial and Glioneuronal Tumours in Adults.Cancers · 2023Review
- Malignant transformation of central neurocytoma with dissemination 17 years after initial treatment: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Impact of Adjuvant Radiotherapy in Patients with Central Neurocytoma: A Multicentric International Analysis.Cancers · 2021Article
- The last decade's experience of management of central neurocytomas: Treatment strategies and new options.Surgical neurology international · 2021Article
- Atypical central neurocytoma with leptomeningeal dissemination: a case report.Journal of the Egyptian National Cancer Institute · 2020Article
- Endoscopic approach and stereotactic radiosurgery for a posterior third ventricular Central Neurocytoma - case report and literature review.International journal of surgery case reports · 2020Article
- The role of chemotherapy in the treatment of central neurocytoma.CNS oncology · 2019Review
- Systematic Analysis of Clinical Outcomes Following Stereotactic Radiosurgery for Central Neurocytoma.Brain tumor research and treatment · 2017Review
- Central Neurocytoma: A Review of Clinical Management and Histopathologic Features.Brain tumor research and treatment · 2016Review
- Clinical outcome and prognostic factors for central neurocytoma: twenty year institutional experience.Journal of neuro-oncology · 2016Article
- Evaluation of the good tumor response of embryonal tumor with abundant neuropil and true rosettes (ETANTR).Journal of neuro-oncology · 2016Review
- Atypical Neurocytoma: Dilemma in diagnosis and management.Surgical neurology international · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central neurocytoma is generally considered to be a benign tumor and the literature suggests that a cure may be attained by surgery ± adjuvant focal irradiation. However, there is a need for change in the therapeutic strategy for the subgroup of patients with aggressive central neurocytoma. An example case is presented and the literature on central neurocytoma cases with malignant features and dissemination via the cerebrospinal fluid is reviewed and the radiotherapeutic strategies available for central neurocytoma treatment is discussed. Nineteen cases including the present report with a malignant course and cerebrospinal fluid dissemination have been described to date, most of them involving an elevated MIB-1 labeling index. Our case exhibited atypical central neurocytoma with an initially elevated MIB-1 labeling index (25-30 %). The primary treatment included surgery and focal radiotherapy. Three years later the disease had disseminated throughout the craniospinal axis. A good tumor response and symptom relief were achieved with repeated radiation and temozolomide chemotherapy. Central neurocytoma with an initially high proliferation activity has a high tendency to spread via the cerebrospinal fluid. The chemo- and radiosensitivity of the tumor suggest a more aggressive adjuvant therapy approach. Cases with a potential for malignant transformation should be identified and treated appropriately, including irradiation of the entire neuroaxis and adjuvant chemotherapy may be considered.
Indexed as
Identifiers
24122623What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.