ArticleIndian journal of pediatrics2013
Epidemiological Features of Aplastic Anemia in Indian Children.
Article in Indian journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Not all thrombocytopenic bleeding is the same: Response to SinghJournal of family medicine and primary care · 2021Article
- Cytomegalovirus and Epstein-Barr Infections: Prevalence and Impact on Patients with Hematological Diseases.BioMed research international · 2020Review
- Patient features and survival of pediatric aplastic anemia in the USA: a large institution experience.Journal of public health (Oxford, England) · 2019Article
- Interaction between Herpes Virus Infections and IL10 and Risk of Bone Marrow Suppression.International journal of organ transplantation medicine · 2018Article
- Microbe-Induced Inflammatory Signals Triggering Acquired Bone Marrow Failure Syndromes.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
objectivesTo study the socio-demographic profile and clinico-hematological features of aplastic anemia in children presenting at a single institution over 5 y.
methodsPatients below the age of 15 y presenting with features of aplastic anemia were included in the study. Epidemiology, clinico-hematological features and treatment received were recorded in all the cases. Serology for hepatitis A, B, C, E, EBV, parvovirus and HIV was carried out. Cytogenetic studies were available in approximately half of the patients.
resultsOne hundred eighty five patients were diagnosed with aplastic anemia. Ten patients with inherited bone marrow failure syndrome (IBMFS) were excluded. Median age was 8 y (range 4-14 y) with a male to female ratio of 2.4:1. Pallor (100 %) followed by bleeding manifestations (83.8 %) and fever (73.5 %) were most common presenting symptoms. One hundred twenty patients (70 %) were classified as severe, 36 (21 %) very severe and 17 (9 %) non-severe aplastic anemia. Viral markers for parvovirus, Epstein barr virus and hepatitis were positive in 25.8 %, 20 % and 6.7 % patients respectively. Six patients had history of varicella infection in recent past (within 6 mo). Very few patients (30) could afford immunosuppressive therapy (IST) and had suboptimal response (29.7 %).
conclusionsMajority of patients had idiopathic aplastic anemia. Very severe aplastic anemia and severe aplastic anemia were frequent. Few patients received IST and had suboptimal response. There is need to establish a national registry for aplastic anemia.
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Registered trials
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