ArticleAge (Dordrecht, Netherlands)2014
Battery of behavioral tests in mice that models age-associated changes in human motor function.
Article in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed.
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- A Comparative Analysis of Grip Strength Evaluation Methods in a Large Cohort of Aged Mice.Journal of cachexia, sarcopenia and muscle · 2025Article
- Short-term daily deflazacort decreases membrane permeability and increases maximum force inAmerican journal of physiology. Cell physiology · 2025Article
- Neurometabolomic impacts of wood smoke and protective benefits of anti-aging therapeutics in aged female C57BL/6J mice.Particle and fibre toxicology · 2025Article
- Review
- Using Computational Video Analysis in Aging Mice to Evaluate the Effects of Chronic Monotherapy, Polypharmacy, and Deprescribing Over Time.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Novel effects of reverse transcriptase inhibitor supplementation in skeletal muscle of old mice.Physiological genomics · 2025Article
- 37 kDa LRP::FLAG enhances telomerase activity and reduces ageing markers in vivo.Cellular and molecular life sciences : CMLS · 2025Article
- Longitudinal Decline of Exercise Capacity in Male and Female Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models.Scientific reports · 2025Article
- A preliminary exploration of establishing a mice model of hypoxic training.Scientific reports · 2025Article
- Wild capuchin monkeys as a model system for investigating the social and ecological determinants of ageing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Biochemical Alterations and Motor Dysfunctions in Corpus Striatum of Rats Brain Exposed to Azo Dyes.Toxicology research · 2024Article
- Longitudinal Decline of Exercise Capacity in Male and Female Mice.bioRxiv : the preprint server for biology · 2024Article
- The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice.GeroScience · 2024Article
- High-intensity exercise training using a rotarod instrument (RotaHIIT) significantly improves exercise capacity in mice.Physiological reports · 2024Article
- Protective effects of apigenin on the brain transcriptome with aging.Mechanisms of ageing and development · 2024Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Motor function in humans can be characterized with tests of locomotion, strength, balance, and endurance. The aim of our project was to establish an analogous test battery to assess motor function in mice. Male C57BL/6 mice were studied at 3 (n = 87), 20 (n = 48) and 26 (n = 43) months of age. Tests assessed locomotion, strength, balance/coordination, and endurance capacity in mice. Motor function was reduced in the older groups of mice for the locomotion, strength, and endurance subdomains (p < 0.001). As indicated with a summary score, motor function declined by 7.4 % from 3 to 20 months and by 13.5 % from 20 to 26 months. Based on comparison with previously published data in humans, the magnitude and relative time course of changes were similar in mice and humans in each subdomain except balance/coordination. Power calculations confirmed that the age-associated differences depicted by several of the individual tests and domain summary scores would be sufficient to assess the efficacy of interventions aimed at prevention or treatment of motor dysfunction with aging. The current study describes a mouse model that characterizes age-associated changes in clinically relevant domains of motor function and indicates that the preclinical model can be used to test strategies to attenuate age-associated declines in motor function.
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