Trial reportEuropean journal of applied physiology2014
The influence of acetaminophen on repeated sprint cycling performance.
Trial report in European journal of applied physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
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Who cites it
20 citing papers in PubMed.
- Caffeine Exerts Neither Ergogenic nor Hypoalgesic Effects on Sprint Interval Exercise with Intensive Exercise-Induced Muscle Pain.Journal of sports science & medicine · 2025Trial
- Caffeine, but not paracetamol (acetaminophen), enhances muscular endurance, strength, and power.Journal of the International Society of Sports Nutrition · 2024Trial
- Acute ingestion of acetaminophen improves cognitive and repeated high intensity short-term maximal performance in well-trained female athletes: a randomized placebo-controlled trial.European journal of applied physiology · 2024Trial
- Tramadol is a performance-enhancing drug in highly trained cyclists: a randomized controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- The Effect of Acetaminophen on Running Economy and Performance in Collegiate Distance Runners.International journal of environmental research and public health · 2022Trial
- Acute acetaminophen ingestion improves performance and muscle activation during maximal intermittent knee extensor exercise.European journal of applied physiology · 2018Trial
- Transcutaneous electrical nerve stimulation reduces exercise-induced perceived pain and improves endurance exercise performance.European journal of applied physiology · 2017Trial
- Low and High Doses of Espresso Coffee Improve Repeated Sprint Performance and Eye-Hand Coordination Following Fatigue Status in Male Basketball Players.Current developments in nutrition · 2024Article
- What is the Effect of Paracetamol (Acetaminophen) Ingestion on Exercise Performance? Current Findings and Future Research Directions.Sports medicine (Auckland, N.Z.) · 2022Review
- The effect of elevated muscle pain on neuromuscular fatigue during exercise.European journal of applied physiology · 2022Article
- Effects of Paracetamol (Acetaminophen) Ingestion on Endurance Performance: A Systematic Review and Meta-Analysis.Sports (Basel, Switzerland) · 2021Review
- Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Doping in Sports, a Never-Ending Story?Advanced pharmaceutical bulletin · 2018Article
- Endurance Performance is Influenced by Perceptions of Pain and Temperature: Theory, Applications and Safety Considerations.Sports medicine (Auckland, N.Z.) · 2018Review
- The 'sensory tolerance limit': A hypothetical construct determining exercise performance?European journal of sport science · 2018Review
- Acetaminophen (Paracetamol): Use beyond Pain Management and Dose Variability.Frontiers in physiology · 2017Article
- No Influence of Transcutaneous Electrical Nerve Stimulation on Exercise-Induced Pain and 5-Km Cycling Time-Trial Performance.Frontiers in physiology · 2017Article
- The effect of transcranial direct current stimulation of the motor cortex on exercise-induced pain.European journal of applied physiology · 2015Article
- Acetaminophen and sport performance: doping or what?European journal of applied physiology · 2014Article
- Factors affecting the regulation of pacing: current perspectives.Open access journal of sports medicine · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to investigate the effect of acetaminophen on repeated sprint cycling performance.
methodsNine recreationally active male participants completed a graded exercise test, a familiarisation set of Wingate Anaerobic Tests (WAnTs) and two experimental sets of WAnTs (8 × 30 s sprints, 2 min active rest intervals). In the experimental WAnTs, participants ingested either 1.5 g acetaminophen or a placebo in a double-blind, randomised, crossover design. During the WAnT trials, participants provided ratings of perceived pain 20 s into each sprint. Mean and peak power output and heart rate were recorded immediately following each sprint, and percentage decrement in mean power output was subsequently calculated.
resultsParticipants cycled at a significantly greater mean power output over the course of 8 WAnTs (p < 0.05) following the ingestion of acetaminophen (391 ± 74 vs. 372 ± 90 W), due to a significantly greater mean power output during sprints 6, 7 and 8 (p < 0.05). Percentage decrements in mean power output were also significantly reduced (p < 0.05) following acetaminophen ingestion (17 ± 14 vs. 24 ± 17 %). No significant differences in peak power output, perceived pain or heart rate were observed between conditions.
conclusionAcetaminophen may have improved performance through the reduction of pain for a given work rate, thereby enabling participants to exercise closer to a true physiological limit. These results suggest that exercise may be regulated by pain perception, and that an increased pain tolerance can improve exercise performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.