ReviewMedicina oral, patologia oral y cirugia bucal2014
Genetic basis of dental agenesis--molecular genetics patterning clinical dentistry.
Review in Medicina oral, patologia oral y cirugia bucal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
- Trial
- Three-dimensional tooth morphology in patients with tooth agenesis and its association to agenesis pattern, severity, and sex.Scientific reports · 2025Article
- Article
- Personalized and Complex Esthetic Oral Rehabilitation in a Case of Non-Syndromic Oligodontia.Journal of personalized medicine · 2024Article
- "Examining the link between tooth agenesis and papillary thyroid cancer: is there a risk factor?" Observational study.Progress in orthodontics · 2024Observational
- Compound heterozygous WNT10A missense variations exacerbated the tooth agenesis caused by hypohidrotic ectodermal dysplasia.BMC oral health · 2024Article
- Case report: Variability in clinical manifestations within a family with incontinentia pigmenti.Frontiers in medicine · 2024Article
- Genetic Factors of Teeth Impaction: Polymorphic and Haplotype Variants ofInternational journal of molecular sciences · 2023Article
- Identification of potential key variants in mandibular premolar hypodontia through whole-exome sequencing.Frontiers in genetics · 2023Article
- Non-syndromic hypodontia of maxillary lateral incisors and its association with other dental anomalies.Progress in orthodontics · 2022Article
- Dose Dependence Effect in BiallelicDiagnostics (Basel, Switzerland) · 2022Article
- A NovelDiagnostics (Basel, Switzerland) · 2022Article
- Article
- Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice.Scientific reports · 2021Article
- The First Report of a Missense Variant inFrontiers in genetics · 2021Article
- Cervicovertebral anomalies and/or normal variants in patients with congenitally bilateral absent maxillary lateral incisors.The Angle orthodontist · 2020Article
- Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy.Inflammation and regeneration · 2020Review
- Dental genetics in Brazil: Where we are.Molecular genetics & genomic medicine · 2018Article
- A biallelic ANTXR1 variant expands the anthrax toxin receptor associated phenotype to tooth agenesis.American journal of medical genetics. Part A · 2018Article
- Heredity, Genetics and Orthodontics - How Much Has This Research Really Helped?Seminars in orthodontics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tooth agenesis is one of the most common congenital malformations in humans. Hypodontia can either occur as an isolated condition (non-syndromic hypodontia) or can be associated with a syndrome (syndromic hypodontia), highlighting the heterogeneity of the condition. Though much progress has been made to identify the developmental basis of tooth formation, knowledge of the etiological basis of inherited tooth loss is still lacking. To date, the mutation spectra of non-syndromic form of familial and sporadic tooth agenesis in humans have revealed defects in various such genes that encode transcription factors, MSX1 and PAX9 or genes that code for a protein involved in canonical Wnt signaling (AXIN2), and a transmembrane receptor of fibroblast growth factors (FGFR1). The aim of this paper is to review the current literature on the molecular mechanisms responsible for selective hypodontia in humans and to present a detailed overview of causative genes and syndromes associated with hypodontia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.