Evidence map›Paper›PMID 24121904›Full record

ArticleMedicina oral, patologia oral y cirugia bucal2014

Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats.

Beatriz Gottberg, Jeanily Berné, Belkis Quiñónez, Eduvigis Solórzano

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicina oral, patologia oral y cirugia bucal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Effects of antibiotics on the developing enamel in neonatal mice.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Beatriz GottbergEdificio del Rectorado, Calle 24, entre Avenidas 2 y 3, Facultad de Odontología, Universidad de Los Andes, Mérida (5101), Venezuela, eduvigis@ula.ve.
Jeanily Berné
Belkis Quiñónez
Eduvigis Solórzano
University of the Andes · VE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledAmoxicillin is an antibiotic widely prescribed; its most frequent side effects are gastrointestinal disorders and hypersensitivity reactions. Over the last 10 years studies have been published which suggest that amoxicillin may cause dental alterations similar to dental fluorosis. Never the less, the results are not conclusive, this is why it was planned the need to make controlled studies on test animals.

objectiveThe purpose of this study was to determine the effect produced by amoxicillin prenatal administration on dental enamel in Wistar rats. STUDY

design12 pregnant adult rats were used distributed into five different groups: witness control (n=2) didn't get any treatment; negative control (n=2) they were prescribed with saline solution; positive control (n=3) they were prescribed with tetracycline 130 mg/kg, and two groups (n=3 and n=2) treated with amoxicillin doses of 50 and 100 mg/kg respectively. The treatments were daily administered by mouth, from the 6th gestation day to the end of gestation. Twenty five days after they were born, the offspring were sacrificed with a sodium pentobarbital overdose, the mandible was dissected and the first lower molars were gotten. The samples were fixed in 10% formaldehyde solution and clinically and histologically observed to determine any enamel disorders.

resultshypomineralization was observed in every single sample of the tetracyclic and amoxicillin treated group 100 mg/kg, meanwhile only 50% from the group administered with 50 mg/kg amoxicillin showed this histological disorder.

conclusionsthe side effect caused by amoxicillin on dental enamel was doses dependent.

Indexed as

AmoxicillinAnimalsAnti-Bacterial AgentsDental EnamelFemaleFetusPregnancyPrenatal Exposure Delayed EffectsRatsRats, WistarAmoxicillinAnti-Bacterial Agents

Identifiers

PMID24121904
PMCPMC3909430
OpenAlexW2108985324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.