ArticleCurrent microbiology2014
pIMP-PH114 carrying bla IMP-4 in a Klebsiella pneumoniae strain is closely related to other multidrug-resistant IncA/C2 plasmids.
Article in Current microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Characteristics of an NDM-1-producing Klebsiella pneumoniae strain belonging to ST105.Antonie van Leeuwenhoek · 2026Article
- Review
- Mobile genetic elements encoding antibiotic resistance genes and virulence genes inFrontiers in microbiology · 2025Review
- Phenotypic and genomic characteristics of clinical IMP-producing Klebsiella spp. Isolates in China.Communications medicine · 2024Article
- Emergence and genomic characteristics of multi-drug-resistantMicrobial genomics · 2024Article
- Molecular characteristics of clinical IMP-producing Klebsiella pneumoniae isolates: novel IMP-90 and integron In2147.Annals of clinical microbiology and antimicrobials · 2023Article
- IncN1 ST7 Epidemic Plasmid Carrying blaIMP-4 in One ST85-TypeInfection and drug resistance · 2021Article
- Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase.Antimicrobial agents and chemotherapy · 2020Article
- Type II and type IV toxin-antitoxin systems show different evolutionary patterns in the global Klebsiella pneumoniae population.Nucleic acids research · 2020Article
- Genomic dynamics of species and mobile genetic elements in a prolonged blaIMP-4-associated carbapenemase outbreak in an Australian hospital.The Journal of antimicrobial chemotherapy · 2020Article
- Integrating multiple genomic technologies to investigate an outbreak of carbapenemase-producing Enterobacter hormaechei.Nature communications · 2020Article
- Complete-Genome Sequencing and Comparative Genomic Characterization of an IMP-4 ProducingInfection and drug resistance · 2020Article
- Characterization of an IMP-4-ProducingInfection and drug resistance · 2020Article
- A novel Tn1696-like composite transposon (Tn6404) harboring blaScientific reports · 2017Article
- Characterization of the Complete Nucleotide Sequences of IncA/CAntimicrobial agents and chemotherapy · 2017Article
- Molecular characterization of clinical IMP-producing Klebsiella pneumoniae isolates from a Chinese Tertiary Hospital.Annals of clinical microbiology and antimicrobials · 2017Article
- Carbapenem-Resistant Acinetobacter baumannii and Enterobacteriaceae in South and Southeast Asia.Clinical microbiology reviews · 2017Review
- Genome and Plasmid Analysis of blaIMP-4-Carrying Citrobacter freundii B38.Antimicrobial agents and chemotherapy · 2016Article
- Characterization of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae from a healthcare region in Hong Kong.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Complete sequence of the multidrug-resistant IncL/M plasmid pIMP-HB623 Cocarrying bla IMP-34 and fosC2 in an Enterobacter cloacae strain associated with medical travel to China.Antimicrobial agents and chemotherapy · 2015Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The IncA/C plasmids are broad host-range vehicles which have been associated with wide dissemination of CMY-2 among Enterobacteriaceae of human and animal origins. Acquired metallo-β-lactamases (MBLs) such as the IMP-type enzymes are increasingly reported in multidrug-resistant Gram-negative bacteria worldwide, particularly in Enterobacteriaceae. We described the complete sequence of the first IMP-4-encoding IncA/C2 plasmid, pIMP-PH114 (151,885 bp), from a sequence type 1 Klebsiella pneumoniae strain that was recovered from a patient who was hospitalized in the Philippines. pIMP-PH114 consists of a backbone from the IncA/C2 plasmids, with the insertion of a novel Tn21-like class 1 integron composite structure (containing the cassette array bla IMP-4-qacG-aacA4-catB3, followed by a class C β-lactamase bla DHA-1 and the mercury resistance operon, merRTPCADE) and a sul2-floR encoding region. Phylogenetic analysis of the IncA/C repA sequences showed that pIMP-PH114 formed a subgroup with other IncA/C plasmids involved in the international spread of CMY-2, TEM-24 and NDM-1. Identical bla IMP-4 arrays have been described among different Enterobacteriaceae and Acinetobacter spp. in China, Singapore and Australia but the genetic context is different. The broad host range of IncA/C plasmids may have facilitated dissemination of the bla IMP-4 arrays among different diverse groups of bacteria.
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