ArticleThe Journal of biological chemistry2013
Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B(0)AT1) by transcriptional and epigenetic networks.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Emerging Insights into the Relationship Between Amino Acid Metabolism and Diabetic Cardiomyopathy.Biomolecules · 2025Review
- Crosstalk Within the Intestinal Epithelium: Aspects of Intestinal Absorption, Homeostasis, and Immunity.Biomedicines · 2024Review
- New Insights Into the Physiopathology of COVID-19: SARS-CoV-2-Associated Gastrointestinal Illness.Frontiers in medicine · 2021Review
- Article
- Hepatocyte nuclear factor 4α regulates megalin expression in proximal tubular cells.Biochemistry and biophysics reports · 2019Article
- Gut health and serum growth hormone levels of broiler chickens fed dietary chitin and chitosan from cricket and shrimp.Poultry science · 2019Article
- Melatonin Improves Laying Performance by Enhancing Intestinal Amino Acids Transport in Hens.Frontiers in endocrinology · 2018Article
- Molecular mechanisms involved in the adaptive regulation of the colonic thiamin pyrophosphate uptake process.American journal of physiology. Cell physiology · 2017Article
- Nutrient sensing by absorptive and secretory progenies of small intestinal stem cells.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Molecular mechanism(s) involved in differential expression of vitamin C transporters along the intestinal tract.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Identification of novel inhibitors of the amino acid transporter BBritish journal of pharmacology · 2017Article
- Mechanism(S) Involved in the Colon-Specific Expression of the Thiamine Pyrophosphate (Tpp) Transporter.PloS one · 2016Article
- Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.The Journal of biological chemistry · 2015Article
- Molecular Mechanisms Mediating the Adaptive Regulation of Intestinal Riboflavin Uptake Process.PloS one · 2015Article
- Amino acids regulate transgene expression in MDCK cells.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterocytes are specialized to absorb nutrients from the lumen of the small intestine by expressing a select set of genes to maximize the uptake of nutrients. They develop from stem cells in the crypt and differentiate into mature enterocytes while moving along the crypt-villus axis. Using the Slc6a19 gene as an example, encoding the neutral amino acid transporter B(0)AT1, we studied regulation of the gene by transcription factors and epigenetic factors in the intestine. To investigate this question, we used a fractionation method to separate mature enterocytes from crypt cells and analyzed gene expression. Transcription factors HNF1a and HNF4a activate transcription of the Slc6a19 gene in villus enterocytes, whereas high levels of SOX9 repress expression in the crypts. CpG dinucleotides in the proximal promoter were highly methylated in the crypt and fully de-methylated in the villus. Furthermore, histone modification H3K27Ac, indicating an active promoter, was prevalent in villus cells but barely detectable in crypt cells. The results suggest that Slc6a19 expression in the intestine is regulated at three different levels involving promoter methylation, histone modification, and opposing transcription factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.