ArticleThe EMBO journal2013
The MADS transcription factor XAL2/AGL14 modulates auxin transport during Arabidopsis root development by regulating PIN expression.
Article in The EMBO journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 99 citations in OpenAlex.
- Mechanisms of auxin action in plant growth and development.Nature reviews. Molecular cell biology · 2025Review
- ARABIDOPSIS HOMOLOG OF TRITHORAX1 impacts lateral root development by epigenetic regulation of targets involved in root system architecture.The New phytologist · 2025Article
- The metabolite itaconate is a transcriptional and posttranslational modulator of plant metabolism, development, and stress response.Science advances · 2025Article
- Hormonal and Transcriptomic Insights into Inflorescence Stalk Elongation in Oil Palm.Plants (Basel, Switzerland) · 2025Article
- Duckweed genomes and epigenomes underlie triploid hybridization and clonal reproduction.Current biology : CB · 2025Article
- An Overview on MADS Box Members in Plants: A Meta-Review.International journal of molecular sciences · 2024Review
- Genomic analyses reveal the stepwise domestication and genetic mechanism of curd biogenesis in cauliflower.Nature genetics · 2024Article
- Synergistic interaction between wheat streak mosaic virus and Triticum mosaic virus modulates wheat transcriptome to favor disease severity.Frontiers in plant science · 2024Article
- The MADS-box genesFrontiers in plant science · 2024Article
- The MADS-box family gene PtrANR1 encodes a transcription activator promoting root growth and enhancing plant tolerance to drought stress.Plant cell reports · 2023Article
- Genome-wide identification of the AcMADS-box family and functional validation ofFrontiers in plant science · 2023Article
- Tapping into the plasticity of plant architecture for increased stress resilience.F1000Research · 2023Review
- Combined Approach of GWAS and Phylogenetic Analyses to Identify New Candidate Genes That Participate inPlants (Basel, Switzerland) · 2022Article
- Regulatory network for FOREVER YOUNG FLOWER-like genes in regulating Arabidopsis flower senescence and abscission.Communications biology · 2022Article
- COE2 Is Required for the Root Foraging Response to Nitrogen Limitation.International journal of molecular sciences · 2022Article
- Red and Blue Light Affect the Formation of Adventitious Roots of Tea Cuttings (Frontiers in plant science · 2022Article
- Systematic analysis of MADS-box gene family in the U's triangle species and targeted mutagenesis ofFrontiers in plant science · 2022Article
- The flowering transition pathways converge into a complex gene regulatory network that underlies the phase changes of the shoot apical meristem inFrontiers in plant science · 2022Article
- Multi-Omics Analysis Reveals a Regulatory Network of ZmCCT During Maize Resistance to Gibberella Stalk Rot at the Early Stage.Frontiers in plant science · 2022Article
- Genome-Wide Analysis of the MADS-Box Gene Family in Holoparasitic Plants (Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elucidating molecular links between cell-fate regulatory networks and dynamic patterning modules is a key for understanding development. Auxin is important for plant patterning, particularly in roots, where it establishes positional information for cell-fate decisions. PIN genes encode plasma membrane proteins that serve as auxin efflux transporters; mutations in members of this gene family exhibit smaller roots with altered root meristems and stem-cell patterning. Direct regulators of PIN transcription have remained elusive. Here, we establish that a MADS-box gene (XAANTAL2, XAL2/AGL14) controls auxin transport via PIN transcriptional regulation during Arabidopsis root development; mutations in this gene exhibit altered stem-cell patterning, root meristem size, and root growth. XAL2 is necessary for normal shootward and rootward auxin transport, as well as for maintaining normal auxin distribution within the root. Furthermore, this MADS-domain transcription factor upregulates PIN1 and PIN4 by direct binding to regulatory regions and it is required for PIN4-dependent auxin response. In turn, XAL2 expression is regulated by auxin levels thus establishing a positive feedback loop between auxin levels and PIN regulation that is likely to be important for robust root patterning.
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