SynthesisNeurotoxicology2013
Neurodevelopmental effects in children associated with exposure to organophosphate pesticides: a systematic review.
Synthesis in Neurotoxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
127 citing papers in PubMed, 9 syntheses or guidelines pooled it, 254 citations in OpenAlex.
- Pesticides and neurodevelopment of children in low and middle-income countries: A systematic review.PloS one · 2025Pooled it
- A Systematic Review and Meta-analysis of Chemical Exposures and Attention-Deficit/Hyperactivity Disorder in Children.Prevention science : the official journal of the Society for Prevention Research · 2024Pooled it
- Pooled it
- Pesticide exposure and child growth in low- and middle-income countries: A systematic review.Environmental research · 2022Pooled it
- Risk Factors for Brain Health in Agricultural Work: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Early exposure to agricultural pesticides and the occurrence of autism spectrum disorder: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2022Pooled it
- Association between pesticide exposure and paraoxonase-1 (PON1) polymorphisms, and neurobehavioural outcomes in children: a systematic review.Systematic reviews · 2020Pooled it
- Respiratory and Allergic Effects in Children Exposed to Pesticides-A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Chronic exposure to organophosphate (OP) pesticides and neuropsychological functioning in farm workers: a review.International journal of occupational and environmental health · 2016Pooled it
- Effect of a 24-week randomized trial of an organic produce intervention on pyrethroid and organophosphate pesticide exposure among pregnant women.Environment international · 2019Trial
- Metals, pesticides, and mycotoxins oral exposure via potato chips ingestion: A Monte Carlo-simulation risk assessment for Iranian consumers.Toxicology reports · 2026Article
- Sustainable Waste-Derived Mineral-Carbon Composites as Reusable Sorbents for Solid-Phase Extraction of Selected Organophosphorus Pesticides from Water.Molecules (Basel, Switzerland) · 2026Article
- Timing of exposure impacts how organophosphorus pesticides affect the developing brain in the planarian Dugesia japonica.Archives of toxicology · 2026Article
- Reliable LC-MS/MS method integrated with a linear retention index approach for multiresidue pesticide analysis in hemp seed oil.Analytical and bioanalytical chemistry · 2026Article
- Occurrence of insecticides, fungicides, and herbicides in household drinking and irrigation water in an intensive floriculture region of Ecuador.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Association of PFAS, Metals, Phthalate and Organophosphate Metabolites with Depression Among U.S. Adults.International journal of environmental research and public health · 2026Article
- Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model.Journal of applied toxicology : JAT · 2026Article
- Organophosphate pesticides: a review on classification, synthesis, toxicity, remediation and analysis.RSC advances · 2025Review
- Article
- Temporal trends of agricultural organophosphate pesticide use in California and proximity to pregnant people in 2021.BMC public health · 2025Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Many studies have investigated the neurodevelopmental effects of prenatal and early childhood exposures to organophosphate (OP) pesticides among children, but they have not been collectively evaluated. The aim of the present article is to synthesize reported evidence over the last decade on OP exposure and neurodevelopmental effects in children. The Data Sources were PubMed, Web of Science, EBSCO, SciVerse Scopus, SpringerLink, SciELO and DOAJ. The eligibility criteria considered were studies assessing exposure to OP pesticides and neurodevelopmental effects in children from birth to 18 years of age, published between 2002 and 2012 in English or Spanish. Twenty-seven articles met the eligibility criteria. Studies were rated for evidential consideration as high, intermediate, or low based upon the study design, number of participants, exposure measurement, and neurodevelopmental measures. All but one of the 27 studies evaluated showed some negative effects of pesticides on neurobehavioral development. A positive dose-response relationship between OP exposure and neurodevelopmental outcomes was found in all but one of the 12 studies that assessed dose-response. In the ten longitudinal studies that assessed prenatal exposure to OPs, cognitive deficits (related to working memory) were found in children at age 7 years, behavioral deficits (related to attention) seen mainly in toddlers, and motor deficits (abnormal reflexes) seen mainly in neonates. No meta-analysis was possible due to different measurements of exposure assessment and outcomes. Eleven studies (all longitudinal) were rated high, 14 studies were rated intermediate, and two studies were rated low. Evidence of neurological deficits associated with exposure to OP pesticides in children is growing. The studies reviewed collectively support the hypothesis that exposure to OP pesticides induces neurotoxic effects. Further research is needed to understand effects associated with exposure in critical windows of development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.