ArticleGenomics
Transcriptome dynamics during human erythroid differentiation and development.
Article in Genomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Global comprehensive transcriptomic and proteomic analyses of murine terminal erythroid differentiation.Global medical genetics · 2025Article
- Article
- EryDB: A Transcriptomic Profile Database for Erythropoiesis and Erythroid-related Diseases.Genomics, proteomics & bioinformatics · 2025Article
- Distinct miRNA Signatures and Networks Discern Fetal from Adult Erythroid Differentiation and Primary from Immortalized Erythroid Cells.International journal of molecular sciences · 2021Article
- Tumor Immune Evasion Induced by Dysregulation of Erythroid Progenitor Cells Development.Cancers · 2021Review
- Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Long noncoding RNABlood science (Baltimore, Md.) · 2019Article
- Article
- Unraveling transcriptome dynamics in human spermatogenesis.Development (Cambridge, England) · 2017Article
- Article
- Investigation of FoxO3 dynamics during erythroblast development in β-thalassemia major.PloS one · 2017Article
- Distinct gene expression program dynamics during erythropoiesis from human induced pluripotent stem cells compared with adult and cord blood progenitors.BMC genomics · 2016Article
- Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells.Development (Cambridge, England) · 2016Article
- A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages.Blood · 2016Article
- MiR-218 Inhibits Erythroid Differentiation and Alters Iron Metabolism by Targeting ALAS2 in K562 Cells.International journal of molecular sciences · 2015Article
- Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp.PloS one · 2015Article
- Transcriptomics and proteomics in stem cell research.Frontiers of medicine · 2014Review
- MicroRNAs: modulators of cell identity, and their applications in tissue engineering.MicroRNA (Shariqah, United Arab Emirates) · 2014Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
To explore the mechanisms controlling erythroid differentiation and development, we analyzed the genome-wide transcription dynamics occurring during the differentiation of human embryonic stem cells (HESCs) into the erythroid lineage and development of embryonic to adult erythropoiesis using high throughput sequencing technology. HESCs and erythroid cells at three developmental stages: ESER (embryonic), FLER (fetal), and PBER (adult) were analyzed. Our findings revealed that the number of expressed genes decreased during differentiation, whereas the total expression intensity increased. At each of the three transitions (HESCs-ESERs, ESERs-FLERs, and FLERs-PBERs), many differentially expressed genes were observed, which were involved in maintaining pluripotency, early erythroid specification, rapid cell growth, and cell-cell adhesion and interaction. We also discovered dynamic networks and their central nodes in each transition. Our study provides a fundamental basis for further investigation of erythroid differentiation and development, and has implications in using ESERs for transfusion product in clinical settings.
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