ArticleGene expression patterns : GEP2013
The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain.
Article in Gene expression patterns : GEP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Reconstructing the molecular life history of gliomas.Acta neuropathologica · 2018Pooled it
- A New Class of Vitamin K Analogues Containing the Side Chain of Retinoic Acid Have Enhanced Activity for Inducing Neuronal Differentiation.ACS chemical neuroscience · 2025Article
- Endogenous neural stem cells characterization using omics approaches: Current knowledge in health and disease.Frontiers in cellular neuroscience · 2023Review
- Comprehensive analysis of the expression, prognosis, and immune infiltrates for CHDs in human lung cancer.Discover oncology · 2022Article
- ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells.Stem cells international · 2020Review
- Chromatin-mediated translational control is essential for neural cell fate specification.Life science alliance · 2018Article
- Genetic variationsOncotarget · 2018Article
- Mice lacking the chromodomain helicase DNA-binding 5 chromatin remodeler display autism-like characteristics.Translational psychiatry · 2017Article
- Defining the transcriptomic landscape of the developing enteric nervous system and its cellular environment.BMC genomics · 2017Article
- ATP-dependent chromatin remodeling during mammalian development.Development (Cambridge, England) · 2016Review
- Retinoic acid-induced CHD5 upregulation and neuronal differentiation of neuroblastoma.Molecular cancer · 2015Article
- The chromatin remodeler chd5 is necessary for proper head development during embryogenesis of Danio rerio.Biochimica et biophysica acta · 2015Article
- The tumour suppressor CHD5 forms a NuRD-type chromatin remodelling complex.The Biochemical journal · 2015Article
- Co-expression network of neural-differentiation genes shows specific pattern in schizophrenia.BMC medical genomics · 2015Article
- Chd5 orchestrates chromatin remodelling during sperm development.Nature communications · 2014Article
- Role of CHD5 in human cancers: 10 years later.Cancer research · 2014Review
- Architects of the genome: CHD dysfunction in cancer, developmental disorders and neurological syndromes.Epigenomics · 2014Review
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Epigenetic regulation of gene expression orchestrates dynamic cellular processes that become perturbed in human disease. An understanding of how subversion of chromatin-mediated events leads to pathologies such as cancer and neurodevelopmental syndromes may offer better treatment options for these pathological conditions. Chromodomain Helicase DNA-binding protein 5 (CHD5) is a dosage-sensitive tumor suppressor that is inactivated in human cancers, including neural-associated malignancies such as neuroblastoma and glioma. Here we report a detailed analysis of the temporal and cell type-specific expression pattern of Chd5 in the mammalian brain. By analyzing endogenous Chd5 protein expression during mouse embryogenesis, in the neonate, and in the adult, we found that Chd5 is expressed broadly in multiple brain regions, that Chd5 sub-cellular localization undergoes a switch from the cytoplasm to the nucleus during mid-gestation, and that Chd5 expression is retained at high levels in differentiated neurons of the adult. These findings may have important implications for defining the role of CHD5-mediated chromatin dynamics in the brain and for elucidating how perturbation of these epigenetic processes leads to neuronal malignancies, neurodegenerative diseases, and neurodevelopmental syndromes.
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