Evidence map›Paper›PMID 24120943›Full record

ArticleCell metabolism2013

Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway.

Christiane D Wrann, James P White, John Salogiannnis, Dina Laznik-Bogoslavski, Jun Wu, Di Ma, Jiandie D Lin, Michael E Greenberg, Bruce M Spiegelman

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 794 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
794citing papers in PubMed, 10 pooled it
26.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04121637 naunknown statusnot on this mapstarted 2019, after this paper: background citation

To Investigate the Effect of Aerobic Exercise on Neurophysiological Values and Functionality in Individuals With Multiple Sclerosis.

TypeinterventionalSponsorFirat UniversityRan2019 to 2020Enrolled22ConditionsMultiple Sclerosis, Relapsing-Remitting, FNDC5, Irisin Hormone, Aerobic ExerciseArmsAerobic Exercise, Frenkel coordination exercises
NCT06870968 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

An Exercise Training Intervention for Depressive Symptoms in Youth With MS: A Randomized Controlled Feasibility Trial

TypeinterventionalSponsorThe Hospital for Sick ChildrenRan2025 to 2026Enrolled40ConditionsNeuroinflammatory Diseases, Multiple SclerosisArmsExercise Training, Mobility and Flexibility Training
3 · Its place in the literature

Who cites it

794 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,326 citations in OpenAlex.

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734 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Christiane D WrannDana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.
James P White
John Salogiannnis
Dina Laznik-Bogoslavski
Jun Wu
Di Ma
Jiandie D Lin
Michael E Greenberg
Bruce M Spiegelman
Dana-Farber Cancer Institute · USHarvard University · USUniversity of Michigan–Ann Arbor · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
CONTROL OF ADIPOCYTE GENE EXPRESSION AND PHYSIOLOGYR37DK031405 · NIDDK · DANA-FARBER CANCER INSTITUTE · PI SPIEGELMAN, BRUCE M. · 1996 to 2013
$8.2M
PGC-1 AND NUCLEAR RECEPTORS IN ADAPTIVE THERMOGENESISR01DK054477 · NIDDK · DANA-FARBER CANCER INSTITUTE · PI SPIEGELMAN, BRUCE M. · 1998 to 2016
$7.0M
Regulation of Brown Fat: Toward New Therapy for Human ObesityRC4DK090861 · NIDDK · DANA-FARBER CANCER INST · PI SPIEGELMAN, BRUCE M. · 2010 to 2010
$4.2M
CONTROL OF LIPOGENIC ENZYME SYNTHESIS IN ADIPOCYTESR01DK031405 · NIDDK · DANA-FARBER CANCER INSTITUTE · PI SPIEGELMAN, BRUCE M. · 1986 to 2018
$2.9M
NIDDK NIH HHS DK31405NIDDK NIH HHS DK90861NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK031405NIDDK NIH HHS R01 DK054477NIDDK NIH HHS R37 DK031405NIDDK NIH HHS RC4 DK090861
6 · The paper itself

Abstract

Exercise can improve cognitive function and has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Here we show that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and secreted as irisin, is also elevated by endurance exercise in the hippocampus of mice. Neuronal Fndc5 gene expression is regulated by PGC-1α, and Pgc1a(-/-) mice show reduced Fndc5 expression in the brain. Forced expression of FNDC5 in primary cortical neurons increases Bdnf expression, whereas RNAi-mediated knockdown of FNDC5 reduces Bdnf. Importantly, peripheral delivery of FNDC5 to the liver via adenoviral vectors, resulting in elevated blood irisin, induces expression of Bdnf and other neuroprotective genes in the hippocampus. Taken together, our findings link endurance exercise and the important metabolic mediators, PGC-1α and FNDC5, with BDNF expression in the brain.

Indexed as

Physical Conditioning, AnimalSignal TransductionAdenoviridaeAnimalsBrain-Derived Neurotrophic FactorERRalpha Estrogen-Related ReceptorFeedback, PhysiologicalFibronectinsGene Expression ProfilingGene Expression Regulation, DevelopmentalGenetic VectorsHippocampusHumansMaleMiceMice, Inbred C57BLBrain-Derived Neurotrophic FactorERRalpha Estrogen-Related ReceptorFibronectinsFNDC5 protein, mousePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseReceptors, EstrogenRecombinant ProteinsTranscription Factors

Identifiers

PMID24120943
PMCPMC3980968
OpenAlexW2147515151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.