ArticleBiologicals : journal of the International Association of Biological Standardization2013
The serological evidence in humans supports a negligible risk of zoonotic infection from porcine circovirus type 2.
Article in Biologicals : journal of the International Association of Biological Standardization, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- DNA porcine viruses detected on fresh liver samples destined for human consumption.Veterinary research communications · 2025Article
- Unknown Circovirus in Immunosuppressed Patient with Hepatitis, France, 2022.Emerging infectious diseases · 2023Article
- Circovirus in Blood of a Febrile Horse with Hepatitis.Viruses · 2021Article
- Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients.Clinical microbiology reviews · 2020Review
- Reservoirs of Porcine Circoviruses: A Mini Review.Frontiers in veterinary science · 2019Review
- Development of luciferase-linked antibody capture assay based on luciferase immunoprecipitation systems for antibody detection of porcine reproductive and respiratory syndrome virus.BMC biotechnology · 2018Article
- Article
- Porcine MKRN1 Modulates the Replication and Pathogenesis of Porcine Circovirus Type 2 by Inducing Capsid Protein Ubiquitination and Degradation.Journal of virology · 2018Article
- New Parvovirus Associated with Serum Hepatitis in Horses after Inoculation of Common Biological Product.Emerging infectious diseases · 2018Article
- Surveillance for respiratory and diarrheal pathogens at the human-pig interface in Sarawak, Malaysia.PloS one · 2018Article
- Preventing transfer of infectious agents.International journal of surgery (London, England) · 2015Review
- The dilemma of rare events: Porcine epidemic diarrhea virus in North America.Preventive veterinary medicine · 2015Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
There are two porcine circovirus (PCV) genotypes, PCV-1 and PCV-2. In pigs, PCV-1 infection is asymptomatic but PCV-2 infection can cause severe respiratory disease and other pathology. Although humans ingest PCV-contaminated foods and are exposed to PCV through other sources, the potential of PCV-2 as a zoonotic agent in humans and other species has not been fully explored. Here, four recombinant proteins derived from the PCV-2 capsid gene were examined as antigens using the Luciferase Immunoprecipitation System (LIPS) assay for serological analysis of PCV-2 infection. PCV-2-CAP-Δ1 was the optimum recombinant protein in the LIPS assay with a sensitivity of 93% and specificity of 100% using porcine samples. Testing of healthy human blood donors, equine and bovine serum samples failed to demonstrate the presence of anti-PCV-2 antibodies. Additionally, analysis of two high-risk human groups, cystic fibrosis patients taking porcine derived oral supplements and type I diabetes patients who had undergone porcine islet cell transplantation, showed no evidence of anti-PCV-2 antibodies. These results extend the extensively demonstrated use of LIPS as a robust approach for identifying humoral responses and provide evidence that PCV-2 is likely not infectious in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.