Evidence map›Paper›PMID 24120656›Full record

ReviewAdvanced drug delivery reviews2013

Nanomedicine therapeutic approaches to overcome cancer drug resistance.

Janet L Markman, Arthur Rekechenetskiy, Eggehard Holler, Julia Y Ljubimova

Open access · hybridAbstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 227 papers.

0numbers the graph read from it
0cells of the map it votes in
227citing papers in PubMed
26.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

227 citing papers in PubMed, 724 citations in OpenAlex.

  1. Review
  2. Article
  3. Selenium-Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Nanomedicine-Based Strategies for Multiple Myeloma Therapy.International journal of nanomedicine · 2026
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
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  19. Article
  20. Review

167 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Janet L MarkmanNanomedicine Research Center, Department of Neurosurgery at Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Arthur Rekechenetskiy
Eggehard Holler
Julia Y Ljubimova
Cedars-Sinai Medical Center · US

Funding

Novel Nanopolymers to Inhibit Angiogenesis and Increase the Anti-tumor ImmunityR01CA136841 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LJUBIMOVA, JULIA Y, PENICHET, MANUEL L · 2010 to 2014
$2.7M
Nanoconjugate based on polymalic acid for brain tumor treatmentU01CA151815 · NCI · CEDARS-SINAI MEDICAL CENTER · PI LJUBIMOVA, JULIA Y · 2010 to 2014
$2.7M
Differential MRI imaging for brain tumor metastases diagnosis and treatment monitoringR01CA188743 · NCI · CEDARS-SINAI MEDICAL CENTER · PI LJUBIMOVA, JULIA Y · 2015 to 2019
$2.5M
Tumor drug delivery systems based on polymalic acidR01CA123495 · NCI · CEDARS-SINAI MEDICAL CENTER · PI LJUBIMOVA, JULIA Y · 2006 to 2010
$1.4M
NCI NIH HHS R01 CA123495NCI NIH HHS R01 CA136841NCI NIH HHS R01 CA188743NCI NIH HHS U01 CA151815
6 · The paper itself

Abstract

Nanomedicine is an emerging form of therapy that focuses on alternative drug delivery and improvement of the treatment efficacy while reducing detrimental side effects to normal tissues. Cancer drug resistance is a complicated process that involves multiple mechanisms. Here we discuss the major forms of drug resistance and the new possibilities that nanomedicines offer to overcome these treatment obstacles. Novel nanomedicines that have a high ability for flexible, fast drug design and production based on tumor genetic profiles can be created making drug selection for personal patient treatment much more intensive and effective. This review aims to demonstrate the advantage of the young medical science field, nanomedicine, for overcoming cancer drug resistance. With the advanced design and alternative mechanisms of drug delivery known for different nanodrugs including liposomes, polymer conjugates, micelles, dendrimers, carbon-based, and metallic nanoparticles, overcoming various forms of multi-drug resistance looks promising and opens new horizons for cancer treatment.

Indexed as

Drug Resistance, MultipleDrug Resistance, NeoplasmAnimalsAntineoplastic AgentsCell Line, TumorClinical Trials as TopicDrug CarriersDrug DesignHumansNanomedicineNanoparticlesNeoplasmsNeoplastic Stem CellsTumor MicroenvironmentAntineoplastic AgentsDrug Carriersacute myeloid leukemiaAMLCAM-DRcancer stem cellCCPcell adhesion-mediated drug resistancecentral nervous systemcharge-conversion polymerchronic lymphocytic leukemiaCLLCNSCSCDrug deliveryEGFRenhanced permeability and retentionepidermal growth factor receptorEPRH(2)N-Leu-Leu-Leu-OHHIF-1hypoxia-inducible factor 1IGF-1RIL-2insulin-like growth factor 1 receptorinterleukin-2LLLmAbMDRmonoclonal antibodyMRPmultidrug resistancemultidrug-resistance-associated proteinNanobiopolymersNanodrugNF-κBnon-small cell lung cancerNSCLCnuclear factor κBPDGFR-βPEGplatelet-derived growth factor receptor-βpolyethylene glycolRESreticuloendothelial systemSDF-1/CXCL12short interfering RNAsiRNAstromal cell-derived factor 1TATtemozolomideTfRTG2tissue transglutaminaseTLRTMZTNFαtoll-like receptortransactivator of transcriptiontransferrin receptorTumor multidrug resistancetumor necrosis factor α

Identifiers

PMID24120656
PMCPMC5812459
OpenAlexW2086374939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.