Trial reportBlood transfusion = Trasfusione del sangue2014
Applying molecular immunohaematology to regularly transfused thalassaemic patients in Thailand.
Trial report in Blood transfusion = Trasfusione del sangue, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Clinical integration of red cell genotyping in children with β-thalassemia major: a prospective observational study.Blood global hematology · 2026Article
- Kidd Blood Group Genotyping for Thalassemia Patient in Iran.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2020Article
- Red Cell Transfusions in the Genomics Era.Seminars in hematology · 2019Review
- Transfusion Support in Patients with Hematologic Disease: New and Novel Transfusion Modalities.Seminars in hematology · 2019Article
- Molecular genotyping of clinically important blood group antigens in patients with thalassaemia.The Indian journal of medical research · 2018Article
- Article
- Rh-Matched Transfusion through Molecular Typing for β-Thalassemia Patients Is Required and Feasible in Chinese.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2018Article
- Two large deletions extending beyond either end of the RHD gene and their red cell phenotypes.Journal of human genetics · 2018Article
- Red cell genotyping precision medicine: a conference summary.Therapeutic advances in hematology · 2017Review
- Red Cell Genotyping by Multiplex PCR Identifies Antigen-Matched Blood Units for Transfusion-Dependent Thai Patients.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2017Article
- Molecular typing for blood group antigens within 40 min by direct polymerase chain reaction from plasma or serum.British journal of haematology · 2017Article
- Article
- Molecular immunohaematology round table discussions at the AABB Annual Meeting, Anaheim 2015.Blood transfusion = Trasfusione del sangue · 2016Article
- The DAU cluster: a comparative analysis of 18 RHD alleles, some forming partial D antigens.Transfusion · 2016Article
- Molecular immunohaematology round table discussions at the AABB Annual Meeting, Denver 2013.Blood transfusion = Trasfusione del sangue · 2015Article
- Comment on "Applying molecular immunohaematology to regularly transfused thalassaemic patients in Thailand".Blood transfusion = Trasfusione del sangue · 2015Article
- Why do we use serological blood group phenotype determination in chronically transfused patients?Blood transfusion = Trasfusione del sangue · 2014Article
- A genetic marker of the ACKR1 gene is present in patients with Type II congenital smell loss who have type I hyposmia and hypogeusia.American journal of otolaryngologyArticle
- Erythrocyte membrane antigen frequencies in patients with Type II congenital smell loss.American journal of otolaryngologyArticle
- A comparison of serological phenotyping and molecular genotyping for Kell, Kidd, and Duffy antigens in multi-transfused thalassemia patients.Asian journal of transfusion scienceArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRed blood cell transfusion is the principal therapy in patients with severe thalassaemias and haemoglobinopathies, which are prevalent in Thailand. Serological red blood cell typing is confounded by chronic transfusion, because of circulating donor red blood cells. We evaluated the concordance of serological phenotypes between a routine and a reference laboratory and with red cell genotyping. MATERIALS AND
methodsTen consecutive Thai patients with β-thalassemia major who received regular transfusions were enrolled in Thailand. Phenotypes were tested serologically at Songklanagarind Hospital and at the National Institutes of Health. Red blood cell genotyping was performed with commercially available kits and a platform.
resultsIn only three patients was the red cell genotyping concordant with the serological phenotypes for five antithetical antigen pairs in four blood group systems at the two institutions. At the National Institutes of Health, 32 of the 100 serological tests yielded invalid or discrepant results. The positive predictive value of serology did not reach 1 for any blood group system at either of the two institutions in this set of ten patients. DISCUSSION: Within this small study, numerous discrepancies were observed between serological phenotypes at the two institutes; red cell genotyping enabled determination of the blood group when serology failed due to transfused red blood cells. We question the utility of serological tests in regularly transfused paediatric patients and propose relying solely on red cell genotyping, which requires training for laboratory personnel and physicians. Red cell genotyping outperformed red cell serology by an order of magnitude in regularly transfused patients.
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