ArticleBehavioural brain research2013
Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Exploring the Link between Altitude of Residence and Smoking Patterns in the United States.International journal of environmental research and public health · 2024Article
- Alprazolam exposure during adolescence induces long-lasting dysregulation in reward sensitivity to morphine and second messenger signaling in the VTA-NAc pathway.Scientific reports · 2023Article
- Nicotine on the developing brain.Pharmacological research · 2023Review
- Alcohol and cannabinoid binges and daily exposure to nicotine in adolescent/young adult rats induce sex-dependent long-term appetitive instrumental learning impairment.Frontiers in behavioral neuroscience · 2023Article
- Sex and age differences in approach behavior toward a port that delivers nicotine vapor.Journal of the experimental analysis of behavior · 2022Article
- Adolescent nicotine and footshock exposure augments adult nicotine self-administration and drug-seeking without affecting baseline anxiety-like behaviour or stress responsivity in male rats.Psychopharmacology · 2021Article
- The reinforcement threshold and elasticity of demand for nicotine in an adolescent rat model of depression.Drug and alcohol dependence · 2021Article
- High-dose adolescent nicotine exposure permits spontaneous nicotine self-administration in adult male rats.Drug and alcohol dependence · 2020Article
- Unique, long-term effects of nicotine on adolescent brain.Pharmacology, biochemistry, and behavior · 2020Review
- An Investigation of Definitions of Experimental Vaping among Youth.Tobacco regulatory science · 2020Article
- Overexpression of corticotropin-releasing factor in the nucleus accumbens enhances the reinforcing effects of nicotine in intact female versus male and ovariectomized female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Status and Future Directions of Preclinical Behavioral Pharmacology in Tobacco Regulatory Science.Behavior analysis (Washington, D.C.) · 2018Article
- Animal Research on Nicotine Reduction: Current Evidence and Research Gaps.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Nicotine produces long-term increases in cocaine reinforcement in adolescent but not adult rats.Brain research · 2017Article
- Nicotine self-administration research: the legacy of Steven R. Goldberg and implications for regulation, health policy, and research.Psychopharmacology · 2016Review
- Reward-centricity and attenuated aversions: An adolescent phenotype emerging from studies in laboratory animals.Neuroscience and biobehavioral reviews · 2016Review
- Adolescent Rats Self-Administer Less Nicotine Than Adults at Low Doses.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
- Estradiol promotes the rewarding effects of nicotine in female rats.Behavioural brain research · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
This study compared nicotine intake and changes in food intake and weight gain in naïve adolescent, naïve adult, and adult rats that were exposed to nicotine during adolescence. An extended intravenous self-administration (IVSA) model was used whereby rats had 23-hour access to saline or increasing doses of nicotine (0.03, 0.06, and 0.09 mg/kg/0.1 mL infusion) for 4-day intervals separated by 3-day periods of abstinence. Rats began IVSA as adolescents (PND 32-34) or adults (PND 75). A separate group of rats was exposed to nicotine via osmotic pumps (4.7 mg/kg) for 14 days during adolescence and then began nicotine IVSA as adults (PND 75). The rats that completed the nicotine IVSA regimen were also tested for nicotine-seeking behavior during extinction. The results revealed that nicotine intake was highest in adolescents followed by adults that were pre-exposed to nicotine during adolescence as compared to naïve adults. A similar pattern of nicotine-seeking behavior was observed during extinction. In contrast to nicotine intake, naïve adults displayed robust appetite and weight suppressant effects of nicotine, an effect that was absent in adolescents and adults that were pre-exposed to nicotine during adolescence. Our findings suggest that adolescence is a unique period of enhanced vulnerability to the reinforcing effects of nicotine. Although adolescents gain weight faster than adults, the food intake and weight suppressant effects of nicotine are reduced during adolescence. Importantly, our findings suggest that adolescent nicotine exposure produces long-lasting consequences that enhance nicotine reward and promote tolerance to the anorectic effects of this drug.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.