Evidence map›Paper›PMID 24120400›Full record

ArticleBehavioural brain research2013

Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia.

Ashley M Blouin, Jongah J Lee, Bo Tao, Dani R Smith, Alexander W Johnson, Jay M Baraban, Irving M Reti

Abstract read
In one paragraph

Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ashley M BlouinDepartment of Psychiatry and Behavioral Sciences Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: ablouin@scripps.edu.
Jongah J Lee
Bo Tao
Dani R Smith
Alexander W Johnson
Jay M Baraban
Irving M Reti

Funding

The Role of NARP in Drug AbuseR01DA016303 · NIDA · JOHNS HOPKINS UNIVERSITY · PI RETI, IRVING M · 2006 to 2013
$3.0M
Immersion in Drug AbuseR25DA021630 · NIDA · JOHNS HOPKINS UNIVERSITY · PI GAUDA, ESTELLE B. · 2007 to 2011
$1.7M
NIDA NIH HHS 5R25DA21630-3NIDA NIH HHS R01 DA016303NIDA NIH HHS R01DA016303NIDA NIH HHS R25 DA021630
6 · The paper itself

Abstract

Narp knockout (KO) mice demonstrate cognitive inflexibility and addictive behavior, which are associated with abnormal reactivity to a novel stimulus. To assess reactivity to novelty, we tested Narp KO and wild-type (WT) mice on a neophobia procedure. Both Narp KO and WT mice showed a similar decrease in consumption upon initial exposure to a novel flavor, but Narp KO mice did not increase consumption with subsequent exposures to the novel flavor like the WT mice. Therefore, Narp KO mice do not have abnormal reactivity to novelty but show deficits in adapting behavior to reflect the updated value of a stimulus.

Indexed as

Adaptation, PsychologicalAnimalsC-Reactive ProteinExploratory BehaviorMiceMice, Inbred C57BLMice, KnockoutMotor ActivityNerve Tissue ProteinsPentraxinsPhobic DisordersRecovery of FunctionTime FactorsC-Reactive ProteinNerve Tissue ProteinsPentraxinsAddictionExtinctionNarpNeophobiaNoveltyRecovery from neophobia

Identifiers

PMID24120400
PMCPMC3867371

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.